Short stature with normal growth hormone stimulation testing: lack of evidence for partial growth hormone deficiency or insensitivity.
Short stature with normal growth hormone stimulation testing: lack of evidence for partial growth hormone deficiency or insensitivity.
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生长激素刺激试验正常的身材矮小：缺乏部分生长激素缺乏或不敏感的证据。
DOI：
10.1159/000079711
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Baron,Jeffrey
中科院分区：
文献类型：
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作者：
Nwosu,BenjaminU;Coco,Marilena;Jones,Joy;Barnes,KevinM;Yanovski,JackA;Baron,Jeffrey
目的 检验身材矮小且 GH 峰值刺激 (pGH) 为 7-10 µg/l 的儿童存在部分 GH 缺乏的假设，并检验 pGH 正常但 IGF-I 水平较低的矮个子儿童存在部分 GH 缺乏或部分 GH 不敏感的假设。设计和患者对 76 名接受身材矮小（身高<第 5 个百分位数）评估的儿童的临床和生化特征进行回顾性分析，其中包括两个性别类固醇引发的 GH 刺激试验。 结果 pGH < 7 µg/l (n= 14) 的患者与 pGH > 7 µg/l (n= 62) 的患者存在显着差异，其父母中身高 (MPH) SDS 较高，身高 SDS 与 MPH SDS 之间差异较大，IGF-I SDS 较低。 pGH 为 7–10 µg/l 的患者 (n= 12) 并不具有介于 pGH < 7 µg/l 和 pGH≥ 10 µg/l 患者之间的特征，而是与 pGH≥ 10 µg/l 的患者相似。 pGH≥7μg/l但IGF-I低(<–2SDS)(n=5)的患者没有表现出介于pGH<7μg/l和pGH≥7μg/l且IGF-I正常的患者之间的中间特征。结论这些数据既不支持pGH为7-10μg/l的儿童有部分GH缺乏的假设，也不支持pGH正常但低于正常的儿童的假设IGF-I 水平有部分 GH 缺乏或不敏感。
ObjectivesTo test the hypothesis that children with short stature and peak stimulated GH (pGH) of 7–10 µg/l have partial GH deficiency and to test the hypothesis that short children with normal pGH but low IGF-I levels have partial GH deficiency or partial GH insensitivity.Design and PatientsRetrospective analysis of the clinical and biochemical profiles of 76 children who underwent an evaluation for short stature (height< 5th percentile) that included two, sex steroid-primed GH stimulation tests.ResultsPatients with pGH< 7 µg/l (n= 14) differed significantly from those with pGH> 7 µg/l (n= 62), having greater midparental height (MPH) SDS, a greater disparity between height SDS and MPH SDS, and lower IGF-I SDS. Patients with pGH of 7–10 µg/l (n= 12) did not have characteristics intermediate between those with pGH< 7 µg/l and those with pGH≧ 10 µg/l, but instead resembled those with pGH≧ 10 µg/l. Patients with pGH≧ 7 µg/l, but low IGF-I (<–2 SDS)(n= 5), did not show characteristics intermediate between those with pGH< 7 µg/l and those with pGH≧ 7 µg/l and normal IGF-I.ConclusionsThese data do not support either the hypothesis that children with pGH of 7–10 µg/l have partial GH deficiency or the hypothesis that children with normal pGH but subnormal IGF-I levels have partial GH deficiency or insensitivity.