Activation of Anterior Cingulate Cortex Extracellular Signal-Regulated Kinase-1 and -2 (ERK1/2) Regulates Acetic Acid-Induced, Pain-Related Anxiety in Adult Female Mice.
Activation of Anterior Cingulate Cortex Extracellular Signal-Regulated Kinase-1 and -2 (ERK1/2) Regulates Acetic Acid-Induced, Pain-Related Anxiety in Adult Female Mice.
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DOI：
10.1267/ahc.12002
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发表时间：
2012-08-30
影响因子：
2.4
通讯作者：
Li F
中科院分区：
文献类型：
--
作者：
Zhong XL;Wei R;Zhou P;Luo YW;Wang XQ;Duan J;Bi FF;Zhang JY;Li CQ;Dai RP;Li F
在内脏疼痛中，焦虑和疼痛同时发生，但这种影响的病因尚未得到很好的描述。众所周知，前扣带皮层（ACC）与对有害刺激的情感反应有关。本研究的目的是确定ACC细胞外信号调节(ERK)-1和2 （ERK1/2）活性在疼痛相关焦虑/抑郁的发展和醋酸（AA）引起的内脏疼痛的不良反应中的作用。通过腹腔注射AA建立雌性昆明小鼠内脏痛模型。我们发现AA注射导致ACC中动态的双侧ERK1/2激活模式。皮下注射有丝分裂原激活细胞外激酶（MEK）抑制剂SL327，在AA注射后2小时抑制ERK1/2的激活，对有害反应没有影响，但确实减轻了焦虑样行为，这是由升高的正迷宫和开放场测试结果确定的。这些数据表明，aa诱导的内脏疼痛激活ACC ERK1/2的表达，而ACC ERK1/2调节内脏疼痛相关的焦虑，但不调节有害反应。
In visceral pain, anxiety and pain occur simultaneously, but the etiogenesis of this effect is not yet well-described. The anterior cingulate cortex (ACC) is known to be associated with the affective response to noxious stimuli. The aim of the current study is to define the role of ACC extracellular signal-regulated (ERK)-1 and-2 (ERK1/2) activity in the development of pain-related anxiety/depression and the nocifensive response in acetic acid (AA)-elicited visceral pain. The model of visceral pain was created by intraperitoneal (ip) injection of AA to female Kunming mice. We found that AA injection resulted in a dynamic, bilateral ERK1/2 activation pattern in the ACC. Inhibition of ERK1/2 activation 2 hr after AA injection by subcutaneous (sc) injection of the mitogen-activating extracellular kinase (MEK) inhibitor, SL327, had no effect on the nocifensive responses, but did attenuate anxiety-like behavior, as determined by elevated plus-maze and open-field testing results. These data suggest that AA-induced visceral pain activates expression of ACC ERK1/2, which regulates visceral pain-related anxiety, but not the nocifensive response.
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影响因子：
3.3
作者：
Wei F;Zhuo M
通讯作者：
Zhuo M
中央杏仁核 NMDA 受体-ERK 通路的激活是大鼠吗啡条件位置偏好表达所必需的
影响因子：
3.7
作者：
Li, Fang;Wang, Xiao-Sheng;Li, Chang-Qi
通讯作者：
Li, Chang-Qi
影响因子：
4.1
作者：
FOLTZ, EL;WHITE, LE
通讯作者：
WHITE, LE
影响因子：
24.5
作者：
Million, M;Wang, L;Taché, Y
通讯作者：
Taché, Y
影响因子：
29.4
作者：
Sakurai, Jun;Obata, Koichi;Noguchi, Koichi
通讯作者：
Noguchi, Koichi