Calculated low density lipoprotein cholesterol levels frequently underestimate directly measured low density lipoprotein cholesterol determinations in patients with serum triglyceride levels ≤ 4.52 mmol/l:: An analysis comparing the LipiDirect® magnetic LDL assay with the Friedewald calculation
Calculated low density lipoprotein cholesterol levels frequently underestimate directly measured low density lipoprotein cholesterol determinations in patients with serum triglyceride levels ≤ 4.52 mmol/l:: An analysis comparing the LipiDirect® magnetic LDL assay with the Friedewald calculation
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DOI：
10.1016/j.cca.2005.08.026
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发表时间：
2006-03-01
影响因子：
5
通讯作者：
Nicolosi, R
中科院分区：
文献类型：
--
作者：
Tighe, DA;Ockene, IS;Nicolosi, R
背景：低密度脂蛋白胆固醇（LDL-C）升高是冠状动脉疾病（CAD）发展的一个确定的危险因素。最近的指南详细说明了治疗目标的具体LDL-C切点。在实践中，LDL-C通常由Friedewald公式（FF）推导。已知血清甘油三酯（TG）浓度为bb0 4.52 mmol/l时，该计算不准确，然而，在具有TG浓度的相对健康患者队列中，其准确性较高
Background: Increased low density lipoprotein cholesterol (LDL-C) is an established risk factor for the development of coronary artery disease (CAD). Recent guidelines detail specific LDL-C cutpoints for therapeutic goals. In practice, LDL-C is usually derived from the Friedewald formula (FF). This calculation is known to be inaccurate with serum triglyceride (TG) concentrations > 4.52 mmol/l, however, its accuracy among relatively healthy patient cohorts with TG concentrations