Audiometric findings in workers exposed to low levels of styrene and noise
Audiometric findings in workers exposed to low levels of styrene and noise
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DOI：
10.1097/00043764-200209000-00002
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发表时间：
2002-09-01
影响因子：
3.2
通讯作者：
Franks, J
中科院分区：
文献类型：
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作者：
Morata, TC;Johnson, AC;Franks, J
对玻璃纤维和金属制品制造厂以及邮件分发终端的工人进行了听力测定和暴露测量（N = 313）。与暴露于噪声或未暴露于噪声的工人相比，暴露于噪声和苯乙烯的工人在 2、3、4 和 6 kHz 处的纯音阈值明显较差。年龄、噪音暴露和尿液扁桃酸（苯乙烯的生物标志物）是满足多元逻辑回归显着性水平标准的变量。每增加 1 岁，听力损失的比值比为 1.19（95% 置信区间 [CI]，1.11-1.28），每分贝 >85 dB(A) 的噪音暴露为 1.18（95% CI 1.01-1.34），尿中每克肌酐每毫摩尔扁桃酸为 2.44（95% CI， 1.01-5.89）。我们的研究结果表明，即使接触低于推荐值的苯乙烯也会对听觉系统产生毒性作用。
Audiometry and exposure measurements were conducted on workers from fiberglass and metal products manufacturing plants and a mail distribution terminal (N = 313). Workers exposed to noise and styrene had significantly worse pure-tone thresholds at 2, 3, 4, and 6 kHz when compared with noise-exposed or nonexposed workers. Age, noise exposure, and urinary mandelic acid (a biologic marker for styrene) were the variables that met the significance level criterion in the multiple logistic regression. The odds ratios for hearing loss were 1.19 for each increment of 1 year of age (95% confidence interval [CI], 1.11-1.28), 1.18 for every decibel >85 dB(A) of noise exposure (95% CI 1.01-1.34), and 2.44 for each millimole of mandelic acid per gram of creatinine in urine (95% CI, 1.01-5.89). Our findings suggest that exposure to styrene even below recommended values had a toxic effect on the auditory system.