Myeloid/T-cell acute lymphoblastic leukemia in children and adults
Myeloid/T-cell acute lymphoblastic leukemia in children and adults
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DOI：
10.4081/pr.2011.s2.e3
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发表时间：
2011-01-01
影响因子：
1.1
通讯作者：
Foa, Robin
中科院分区：
文献类型：
--
作者：
Chiaretti, Sabina;Tavolaro, Monica Messina Simona;Foa, Robin
直到最近，在t细胞急性淋巴细胞白血病（T-ALL）中很少发现分子畸变，而且它们仅限于涉及t细胞受体（TCR）的畸变。强大技术的引入使我们能够识别出新的重排。在此背景下，我们对诊断为T-ALL的成年患者进行了基因表达谱分析。通过无监督聚类，我们确定了5个子组。其中，一个分支包括7例（10%）基因表达谱与AML相似的患者。这些病例的特点是大量髓系相关基因以及miR-223过表达。最后，这些患者似乎有一个不利的临床过程。这个新发现的T-ALL病例亚群部分类似于所谓的ETP（早期t前体）儿科亚群：这两个年龄组实际上都有一种特殊的基因表达谱，结果不利，发病率约为10%。
Until recently, few molecular aberrations were recognized in T-cell acute lymphoblastic leukemia (T-ALL) and they were restricted to aberrations involving the T-cell receptor (TCR). The introduction of powerful technologies has allowed to identify novel rearrangements. In this context, we have performed a gene expression profiling analysis on a relatively large cohort (n= 69) of adult patients with a diagnosis of T-ALL. By unsupervised clustering, we identified 5 subgroups. Of these, one branch included 7 patients (10%) whose gene expression profile resembled that of AML. These cases were characterized by the overexpression of a large set of myeloid-related genes, as well as of miR-223. Finally, these patients appear to have an unfavorable clinical course. This newly identified subset of T-ALL cases partly resembles the so-called ETP (early T-precursor) pediatric subgroup: both age groups have in fact a peculiar gene expression profile, an unfavorable outcome and an incidence of about 10%.