Spectral signatures of viewing a needle approaching one's body when anticipating pain
Spectral signatures of viewing a needle approaching one's body when anticipating pain
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DOI：
10.1111/ejn.12304
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发表时间：
2013-10-01
影响因子：
3.4
通讯作者：
Senkowski, Daniel
中科院分区：
文献类型：
--
作者：
Hoefle, Marion;Pomper, Ulrich;Senkowski, Daniel
当看到注射器的针头接近你的皮肤时，对刺痛的预期可能会导致兴奋增加。这种预期如何反映在神经振荡活动中，以及它与自主神经系统内的活动有何关系，目前尚不清楚。最近，我们发现，与棉签触摸相比，观看针刺会增加瞳孔扩张反应（PDR）和感知电刺激的不愉快感。在这里，我们使用高密度脑电图来研究当观察针接近被认为是自己的手时，预期振荡活动是否可以预测电刺激和 PDR 的不愉快。我们展示了针刺和棉签触摸的视频剪辑，并提供了时空对齐的疼痛和无痛皮内电刺激。与棉签触摸相比，当参与者看到针刺时，他们对电刺激和 PDR 的不愉快感会增强。使用线性波束形成的源重建显示，与棉签触摸相比，当参与者观看针刺时，在电刺激开始之前，后扣带皮层 (PCC) 和梭状回的 α 带活动减少。此外，PCC 中的 α 带活动可在单一试验水平上预测 PDR。 PCC 中α带活性的预期减少可能反映了一种神经机制，该机制通过促进充分的防御反应的准备来保护身体免受即将到来的伤害。
When viewing the needle of a syringe approaching your skin, anticipation of a painful prick may lead to increased arousal. How this anticipation is reflected in neural oscillatory activity and how it relates to activity within the autonomic nervous system is thus far unknown. Recently, we found that viewing needle pricks compared with Q-tip touches increases the pupil dilation response (PDR) and perceived unpleasantness of electrical stimuli. Here, we used high-density electroencephalography to investigate whether anticipatory oscillatory activity predicts the unpleasantness of electrical stimuli and PDR while viewing a needle approaching a hand that is perceived as one's own. We presented video clips of needle pricks and Q-tip touches, and delivered spatiotemporally aligned painful and nonpainful intracutaneous electrical stimuli. The perceived unpleasantness of electrical stimuli and the PDR were enhanced when participants viewed needle pricks compared with Q-tip touches. Source reconstruction using linear beamforming revealed reduced alpha-band activity in the posterior cingulate cortex (PCC) and fusiform gyrus before the onset of electrical stimuli when participants viewed needle pricks compared with Q-tip touches. Moreover, alpha-band activity in the PCC predicted PDR on a single trial level. The anticipatory reduction of alpha-band activity in the PCC may reflect a neural mechanism that serves to protect the body from forthcoming harm by facilitating the preparation of adequate defense responses.