Cross-reactive responses to modified M1₅₈-₆₆ peptides by CD8⁺ T cells that use noncanonical BV genes can describe unknown repertoires.
Cross-reactive responses to modified M1₅₈-₆₆ peptides by CD8⁺ T cells that use noncanonical BV genes can describe unknown repertoires.
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DOI：
10.1002/eji.201242596
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发表时间：
2012-11
影响因子：
5.4
通讯作者：
Gorski, Jack
中科院分区：
文献类型：
--
作者：
Petrova, Galina V.;Gorski, Jack
Memory T-cell repertoires are populated by clonotypes selected by an individual’s history of antigen exposures. Our previous analysis of middle-age CD8+ T-cell memory repertoires to the influenza-derived epitope M158-66, described a network of highly cross-reactive BV19 clonotypes responding to M158-66 and at least one peptide with a conservative amino acid substitution at either of two TCR contact positions. Here we report that some substitutions abrogate BV19 responses and favor responses with different BV. Cross-reactive T-cells using seven other BV families responded to 12 of 13 peptides tested. BV12 clonotypes define the most extensive cross-reactive network which encompasses seven peptides. We generated three-dimensional networks based on the peptides recognized and BV family used and observed a cluster of five peptides that includes M158-66 and another cluster of five peptides that does not include M158-66. The first cluster represents peptides structurally similar to M158-66, and the second represents peptides with more considerable changes in epitope recognition surface. We hypothesize that the second cluster represents the cross-reactive network around another unknown epitope or epitopes. This data supports a model of stable CD8+ T-cell memory networks that includes a substantial contribution from cross-reactive T-cells.
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