Electrically conducting polymers for bio-interfacing electronics: From neural and cardiac interfaces to bone and artificial tissue biomaterials
Electrically conducting polymers for bio-interfacing electronics: From neural and cardiac interfaces to bone and artificial tissue biomaterials
复制标题
DOI：
10.1016/j.bios.2020.112620
复制
发表时间：
2020-12-15
影响因子：
12.6
通讯作者：
Shim, Bong Sup
中科院分区：
文献类型：
--
作者：
Lee, Seunghyeon;Ozlu, Busra;Shim, Bong Sup
导电性聚合物（CPs）作为植入式生物电子学材料，由于其独特的特性，如电子-离子杂化导电性、机械柔软性、易于化学改性以及适度的生物相容性，正受到越来越多的关注。CPs已被广泛应用于神经工程、再生医学、多功能传感器和执行器等领域。本文综述了用于生物界面电子学的高分子材料的设计，包括复合材料、导电水凝胶和电化学沉积。我们首先阐述了CPs的基本材料特性，包括生物电化学电荷转移机制，并将它们与自然衍生的CPs进行了对比。然后，我们介绍了CPs生物电子和生物医学应用的最新关键例子，包括神经记录和刺激、组织再生、可拉伸电子和机械驱动。最后，我们对生物界面电子学中CPs当前的材料挑战进行了展望。
Conductive polymers (CPs) are gaining considerable attention as materials for implantable bioelectronics due to their unique features such as electronic-ionic hybrid conductivity, mechanical softness, ease of chemical modification, as well as moderate biocompatibility. CPs have been utilized for a wide range of applications including neural engineering, regenerative medicine, multi-functional sensors and actuators. This review focuses on CP materials design for use in bio-interfacing electronics including composites, conductive hydrogels, and electrochemical deposition. We start by elaborating on the fundamental materials characteristics of CPs, including bioelectrochemical charge-transfer mechanisms, and contrast them with naturally derived CPs. We then present recent critical examples of the bioelectronic and biomedical applications of CPs, including neural recording and stimulation, tissue regeneration, stretchable electronics, and mechanical actuation. We conclude with a perspective of the current material challenges of CPs in bio-interfacing electronics.