Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential.
Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential.
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DOI：
10.1021/acs.bioconjchem.9b00025
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发表时间：
2019-03
影响因子：
4.7
通讯作者：
Khushboo Singh;Wardah Ejaz;K. Dutta;S. Thayumanavan
中科院分区：
文献类型：
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作者：
Khushboo Singh;Wardah Ejaz;K. Dutta;S. Thayumanavan
蛋白质作为多种疾病的生物治疗剂引起了快速增长的兴趣。尤其是抗体，由于其显着的靶标特异性和低免疫原性，作为药物具有巨大的潜力。尽管市场上有许多针对细胞外靶点的抗体，但它们在靶向治疗上重要的细胞内靶点方面的用途因其无法穿过细胞膜而受到限制。认识到抗体疗法在疾病治疗中的潜力，在细胞内递送抗体的方法的开发方面取得了进展。在这篇综述中，我们讨论了各种抗体递送平台及其优点和缺点。
Proteins have sparked fast growing interest as biological therapeutic agents for several diseases. Antibodies, in particular, carry an enormous potential as drugs owing to their remarkable target specificity and low immunogenicity. Although the market has numerous antibodies directed toward extracellular targets, their use in targeting therapeutically important intracellular targets is limited by their inability to cross cellular membrane. Realizing the potential for antibody therapy in disease treatment, progress has been made in the development of methods to deliver antibodies intracellularly. In this review, we address various platforms for delivery of antibodies and their merits and drawbacks.