Natriuretic Peptides and Cardiometabolic Health.
Natriuretic Peptides and Cardiometabolic Health.
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DOI：
10.1253/circj.cj-15-0589
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Wang TJ
中科院分区：
文献类型：
--
作者：
Gupta DK;Wang TJ
利钠肽是一种心脏衍生激素，具有一系列保护功能，包括利钠、利尿、血管扩张、利尿、脂肪分解、减肥和改善胰岛素敏感性。这些作用是通过膜结合的鸟苷酸环酶介导的，该酶导致细胞内第二信使cGMP的产生。越来越多的证据表明，钠尿肽系统的遗传和后天缺陷会导致高血压、心肌肥厚、肥胖、糖尿病、代谢综合征和心力衰竭。在临床上，利钠肽是强有力的诊断和预后标记物，增加利钠肽是心脏代谢性疾病治疗策略的目标。这篇综述将总结目前对利钠肽生物学的理解，并突出新的方面。
Natriuretic peptides are cardiac-derived hormones with a range of protective functions, including natriuresis, diuresis, vasodilation, lusitropy, lipolysis, weight loss, and improved insulin sensitivity. The actions are mediated through membrane bound guanylyl cyclases that lead to production of the intracellular second-messenger cGMP. A growing body of evidence demonstrates that genetic and acquired deficiencies of the natriuretic peptide system can promote hypertension, cardiac hypertrophy, obesity, diabetes mellitus, the metabolic syndrome, and heart failure. Clinically, natriuretic peptides are robust diagnostic and prognostic markers and augmenting natriuretic peptides is a target for therapeutic strategies in cardio-metabolic disease. This review will summarize current understanding and highlight novel aspects of natriuretic peptide biology.