Physiological and Psychological Changes Following Liposuction of Large Volumes of Fat in Overweight and Obese Women.
Physiological and Psychological Changes Following Liposuction of Large Volumes of Fat in Overweight and Obese Women.
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超重和肥胖女性大量脂肪吸脂后的生理和心理变化。
DOI：
10.15436/2376-0494.15.032
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Giese SY
中科院分区：
文献类型：
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作者：
Geliebter A;Krawitz E;Ungredda T;Peresechenski E;Giese SY
抽脂可以去除体内大量的脂肪。我们调查了大量脂肪抽脂对超重/肥胖女性的人体测量学、身体成分（BIA）、代谢激素和心理测量的影响。据我们所知，这是第一次研究人体吸脂后的生理和心理变化。9例绝经前健康超重/肥胖妇女（年龄= 35.9±7.1 SD，体重= 84.4 kg±13.6,BMI = 29.9 kg/m2±2.9）行抽脂术，抽脂3.92 kg±1.04 SD。禁食一晚后，分别在基线（术前一周）和术后（第1、4、12周）测量身高、体重、腰围和臀围。抽取血液样本检测葡萄糖、胰岛素、瘦素和胃饥饿素的空腹浓度。采用体型问卷（BSQ）、身体畸形障碍（BDD）检查自我报告（BDDE-SR）和Zung抑郁自评量表（ZDS）。体重、BMI、腰围和体脂随时间持续下降（p < 0.05）。葡萄糖无明显变化，但胰岛素从第1周到第12周下降（p < 0.05）。瘦素从基线到第1周下降（p = 0.01）；Ghrelin升高但不明显。体脂和腰围的变化（基线至第1周）与此期间胰岛素的变化呈正相关，与胃饥饿素的变化呈负相关（p < 0.05）。BSQ评分随时间显著下降（p = 0.004），但BDDE-SR评分（p = 0.10）和ZDS评分（p = 0.24）无显著变化。抽脂导致体重、脂肪、腰围和瘦素水平显著下降。体脂和腰围的变化与脂肪相关激素、胰岛素和胃饥饿素的同步变化相关（基线至第1周），体型感知得到改善。因此，除了明显的美容效果外，吸脂还会导致一些积极的身体成分、荷尔蒙和心理变化。
Liposuction can remove a substantial amount of body fat. We investigated the effects of liposuction of large volumes of fat on anthropometrics, body composition (BIA), metabolic hormones, and psychological measures in overweight/obese women. To our knowledge, this is the first study to examine both physiological and psychological changes following liposuction of large volumes of fat in humans. Nine premenopausal healthy overweight/obese women (age = 35.9 ± 7.1 SD, weight = 84.4 kg ± 13.6, BMI = 29.9 kg/m2 ± 2.9) underwent liposuction, removing 3.92 kg ± 1.04 SD of fat. Following an overnight fast, height, weight, waist, and hip circumferences were measured at baseline (one week pre-surgery) and post-surgery (wk 1,4,12). Blood samples were drawn for fasting concentrations of glucose, insulin, leptin, and ghrelin. The Body Shape Questionnaire (BSQ), Body Dysmorphic Disorder (BDD) Examination Self-Report (BDDE-SR), and Zung Self-Rating Depression Scale (ZDS) were administered. Body weight, BMI, waist circumference, and body fat consistently decreased over time (p < .05). Glucose did not change significantly, but insulin decreased from wk 1 to wk 12 (p < .05). Leptin decreased from baseline to wk 1 (p = .01); ghrelin increased but not significantly. Changes in body fat and waist circumference (baseline to wk 1) correlated positively with changes in insulin during that period, and correlated inversely with changes in ghrelin (p < .05). BSQ scores decreased significantly over time (p = .004), but scores for BDDE-SR (p = .10) and ZDS (p = .24) did not change significantly. Liposuction led to significant decreases in body weight and fat, waist circumference, and leptin levels. Changes in body fat and waist circumference correlated with concurrent changes in the adipose-related hormones, insulin and ghrelin (baseline to wk 1), and body shape perception improved. Thus, besides the obvious cosmetic effects, liposuction led to several positive body composition, hormonal, and psychological changes.