Prognostic factors for malignant mesothelioma in 142 patients: validation of CALGB and EORTC prognostic scoring systems
Prognostic factors for malignant mesothelioma in 142 patients: validation of CALGB and EORTC prognostic scoring systems
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DOI：
10.1136/thorax.55.9.731
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发表时间：
2000-09-01
期刊：
影响因子：
10
通讯作者：
O'Byrne, KJ
中科院分区：
文献类型：
--
作者：
Edwards, JG;Abrams, KR;O'Byrne, KJ
恶性间皮瘤的发病率正在上升。有一种看法认为，英国的生存状况比其他国家更差。然而，根据准确的预后数据比较不同系列的生存率是很重要的。欧洲癌症研究和治疗组织（EORTC）和癌症和白血病组B（CALGB）最近公布了预后评分系统。我们已经评估了预后变量，验证EORTC和CALGB预后组，并评估了一系列的142 patients. Methods，142例连续出现在莱斯特自1988年以来的患者的生存情况进行了审查。采用考克斯比例风险回归模型对预后变量进行单变量分析。在一个向前的逐步多变量模型中进一步分析统计学显著变量。EORTC和CALGB的预后组，Kaplan-Meier生存曲线绘制，生存率计算从生命表。结果-在单因素分析中显着的不良预后因素包括男性，年龄较大，体重减轻，胸痛，体力状态差，低血红蛋白，白细胞增多，血小板增多，和非上皮细胞类型（P
Background-The incidence of malignant mesothelioma is increasing. There is the perception that survival is worse in the UK than in other countries. However, it is important to compare survival in different series based on accurate prognostic data. The European Organisation for Research and Treatment of Cancer (EORTC) and the Cancer and Leukaemia Group B (CALGB) have recently published prognostic scoring systems. We have assessed the prognostic variables, validated the EORTC and CALGB prognostic groups, and evaluated survival in a series of 142 patients.Methods-Case notes of 142 consecutive patients presenting in Leicester since 1988 were reviewed. Univariate analysis of prognostic variables was performed using a Cox proportional hazards regression model. Statistically significant variables were analysed further in a forward, stepwise multivariate model. EORTC and CALGB prognostic groups were derived, Kaplan-Meier survival curves plotted, and survival rates were calculated from life tables.Results-Significant poor prognostic factors in univariate analysis included male sex, older age, weight loss, chest pain, poor performance status, low haemoglobin, leukocytosis, thrombocytosis, and non-epithelial cell type (p