Asymmetric cyclizations via a sequential Michael addition/Conia-ene reaction by combining multifunctional quaternary phosphonium salt and silver catalysis
Asymmetric cyclizations via a sequential Michael addition/Conia-ene reaction by combining multifunctional quaternary phosphonium salt and silver catalysis
复制标题
结合多功能季鏻盐和银催化，通过顺序迈克尔加成/Conia-ene反应进行不对称环化
DOI：
10.1016/j.tet.2019.03.045
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发表时间：
2019-05-03
期刊：
影响因子：
2.1
通讯作者：
Zhao, Gang
中科院分区：
文献类型：
--
作者：
Fang, Guosheng;Zheng, Changwu;Zhao, Gang
一锅法不对称Michael加成/Conia-ene反应序列由二肽衍生的多官能季膦盐和Ag2CO3催化，以中等到优异的产率(高达97%)和对映体选择性(高达93%)提供了一系列合成重要的手性亚甲基环戊烷衍生物。(C)2019爱思唯尔有限公司。保留所有权利。
A one-pot asymmetric Michael addition/Conia-ene reaction sequence, catalyzed by combination of a dipeptide-derived multifunctional quaternary phosphonium salt and Ag2CO3 has been developed, which provides a series of synthetically important chiral methylenecyclopentane derivatives in moderate to excellent yields (up to 97%) and enantioselectivities (up to 93%). (C) 2019 Elsevier Ltd. All rights reserved.