Lithiation of Diamine Ligands to Chiral Building Blocks: Syntheses, Selectivities, and Lithiated Intermediates
Lithiation of Diamine Ligands to Chiral Building Blocks: Syntheses, Selectivities, and Lithiated Intermediates
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DOI：
10.1021/om100035g
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发表时间：
2010-04-12
期刊：
影响因子：
2.8
通讯作者：
Strohmann, Carsten
中科院分区：
文献类型：
--
作者：
Gessner, Viktoria H.;Strohmann, Carsten
报道了手性氮配体（R，R）-TECDA（2）和（R，R）-TEMCDA（6）与叔丁基锂的直接脱质子化反应。锂化反应的区域选择性可以通过分离的预配位中间体如tBuLi来解释。（R，R）-TECDA与计算研究相结合。
The direct deprotonation of the chiral nitrogen ligands (R,R)-TECDA (2) and (R,R)-TEMCDA (6) with tert-butyllithium to highly reactive building blocks is reported. The regioselectivity of the lithiation reactions can be explained by the isolated precoordinated intermediates such as tBuLi.(R,R)-TECDA in combination with computational studies.