Risperidone in pervasive developmental disorders.
Risperidone in pervasive developmental disorders.
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DOI：
10.1586/14737175.5.6.713
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发表时间：
2005-11-01
影响因子：
4.3
通讯作者：
McDougle, Christopher J
中科院分区：
文献类型：
--
作者：
Erickson, Craig A;Stigler, Kimberly A;McDougle, Christopher J
非典型抗精神病药物越来越多地用于治疗广泛性发育障碍患者的严重行为障碍。在这些化合物中，利培酮是研究最广泛的。这份药物简介将回顾有关利培酮在普适性发育障碍患者中使用的现有数据。此外，还对利培酮的化学、药代动力学、药效学和代谢进行了讨论。重点将放在这些人与利培酮相关的不良反应上，包括讨论可以采取的措施来监测这些影响。最后，将讨论利培酮在这一人群中的未来使用方向和关键问题。
Atypical antipsychotics are increasingly used in the treatment of severe behavioral disturbances in people with pervasive developmental disorders. Among these compounds, risperidone has been the most broadly studied. This drug profile will review the available data on the use of risperidone in individuals with pervasive developmental disorders. In addition, the chemistry, pharmacokinetics, pharmacodynamics and metabolism of risperidone are discussed. Emphasis will be placed on adverse effects associated with risperidone in these people, including a discussion of measures that can be taken to monitor for these effects. Finally, a discussion of the future direction of risperidone use in this population and key issues will be presented.