Surface modification of fused deposition modeling ABS to enable rapid prototyping of biomedical microdevices
Surface modification of fused deposition modeling ABS to enable rapid prototyping of biomedical microdevices
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DOI：
10.1016/j.jmatprotec.2012.12.015
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发表时间：
2013-06-01
影响因子：
6.3
通讯作者：
Yadavalli, Vamsi K.
中科院分区：
文献类型：
--
作者：
McCullough, Eric J.;Yadavalli, Vamsi K.
采用聚丙烯腈-丁二烯-苯乙烯（ABS）的熔融沉积建模（FDM）已成为一种强大的快速成型方法。然而，到目前为止，由于其透水性和生物污垢性，该技术还不适合用于与生物分子和细胞相互作用的微型设备的3D打印。在本文中，提出了一种通用的方法来修改ABS熔融沉积建模具有微结构特征的快速原型装置的表面，使其具有不透水，亲水性和生物相容性。描述了一种基于丙酮的密封方法，该方法对表面粗糙度和结构保真度的影响最小。光诱导聚乙二醇官能团在ABS表面上的接枝聚合用于增加ABS的亲水性和增加对非特异性蛋白质粘附的抵抗力。这些表面被表征为它们的形态、水接触角和模型蛋白的粘附，以证明它们具有更好的生物相容性。所提出的方法使用廉价、安全和广泛可用的材料，这将使使用FDM创建生物相容性表面经济、快速，并扩大该技术的应用范围。(c) 2013 Elsevier B.V.版权所有
Fused deposition modeling (FDM) using poly (acrylonitrile butadiene styrene) (ABS) has emerged as a powerful method in rapid prototyping. However, to date this technique has not been suitable for use in 3D printing of microdevices that interact with biological molecules and cells owing to its water permeability and biofouling nature. In this paper, a versatile method to modify surfaces of ABS fused deposition modeling rapid prototyped devices with microstructured features to render them water-impermeable, hydrophilic, and biocompatible is presented. An acetone-based sealing method is described that has a minimal effect on surface roughness and structural fidelity. Photo-induced graft polymerization of poly (ethylene glycol) functionalities onto the surface is used to increase the hydrophilicity of the ABS and increase resistance to non-specific protein adhesion. These surfaces have been characterized for their morphology, water contact angle and the adhesion of a model protein to demonstrate their improved biocompatibility. The proposed methods use cheap, safe, and widely available materials which should make the creation of biocompatible surfaces using FDM economical, fast, and expand the range of applications of this technique. (c) 2013 Elsevier B.V. All rights reserved.