THE ALTERNATIVE SIGMA-FACTOR KATF (RPOS) REGULATES SALMONELLA VIRULENCE
THE ALTERNATIVE SIGMA-FACTOR KATF (RPOS) REGULATES SALMONELLA VIRULENCE
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DOI：
10.1073/pnas.89.24.11978
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发表时间：
1992-12-15
影响因子：
11.1
通讯作者：
GUINEY, DG
中科院分区：
文献类型：
--
作者：
FANG, FC;LIBBY, SJ;GUINEY, DG
营养限制是沙门氏菌毒力基因调控的关键信号。 katF (rpoS) 基因在细菌饥饿期间介导沙门氏菌 spv 质粒毒力基因的表达。 katF沙门氏菌突变体对营养缺乏、氧化应激、酸应激和DNA损伤的敏感性增加，这些条件与宿主巨噬细胞的吞噬体内环境有关。此外，katF突变体对小鼠的毒力显着降低。 katF 编码 RNA 聚合酶的替代 sigma 因子，协调调节沙门氏菌毒力。
Nutrient limitation is a critical signal in Salmonella virulence gene regulation. The katF (rpoS) gene mediates the expression of the Salmonella spv plasmid virulence genes during bacterial starvation. A katF Salmonella mutant has increased susceptibility to nutrient deprivation, oxidative stress, acid stress, and DNA damage, conditions which are relevant to the intraphagosomal environment of host macrophages. Moreover, the katF mutant has significantly reduced virulence in mice. katF encodes an alternative sigma factor of RNA polymerase which coordinately regulates Salmonella virulence.