THE CONTROL OF HUMAN PANCREATIC ADENOCARCINOMA XENOGRAFTS IN NUDE-MICE BY HORMONE-THERAPY
THE CONTROL OF HUMAN PANCREATIC ADENOCARCINOMA XENOGRAFTS IN NUDE-MICE BY HORMONE-THERAPY
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DOI：
10.1002/bjs.1800691013
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发表时间：
1982-01-01
影响因子：
9.6
通讯作者：
WILLIAMS, R
中科院分区：
文献类型：
--
作者：
GREENWAY, B;DUKE, D;WILLIAMS, R
研究了激素治疗对人非内分泌胰腺腺癌异种移植裸鼠生长的影响。雄激素睾酮刺激肿瘤生长速度，而抗雄激素醋酸环丙孕酮与未治疗对照相比显著抑制肿瘤生长速度。这些发现进一步支持了胰腺癌的生长和代谢可能依赖于性类固醇激素的观点。
The effect of hormone therapy on the growth of human non‐endocrine pancreatic adenocarcinoma xenografts in nude mice was evaluated. The androgen testosterone stimulated tumour growth rate, whereas the anti‐androgen cyproterone acetate significantly inhibited tumour growth rate compared with untreated controls. These findings provide further support for the suggestion that the growth and metabolism of pancreatic carcinoma may be dependent on the sex steroid hormones.