Simulating Tissue Morphogenesis and Signaling
Simulating Tissue Morphogenesis and Signaling
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DOI：
10.1007/978-1-4939-1164-6_21
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发表时间：
2015-01-01
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影响因子：
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通讯作者：
Menshykau, Denis
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文献类型：
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作者：
Iber, Dagmar;Tanaka, Simon;Menshykau, Denis
在胚胎发育过程中，组织形态发生和信号转导紧密耦合。因此，在发育过程的计算机模型中同时模拟组织形态发生和信号转导是很重要的。进程的解决取决于感兴趣的问题。作为本章的一部分，我们介绍了S对组织形态发生的不同描述。在最简单的近似下，组织是一个连续的区域，组织扩张是根据预先定义的时间(可能还有空间)的函数来描述的。在稍微先进的版本中，组织的扩张速度和方向可能取决于结构域上进化的信号变量。这两个版本都将被称为“规定的增长”。或者，组织可以看作是不可压缩的流体，可以用Navier-Stokes方程来描述。然后，局部细胞扩张、增殖和死亡被包含在一个源项中。在其他应用中，单元边界可能很重要，必须引入基于单元的模型。最后，细胞可以在组织内移动，这一过程最好地用基于代理的模型来描述。
During embryonic development tissue morphogenesis and signaling are tightly coupled. It is therefore important to simulate both tissue morphogenesis and signaling simultaneously in in silico models of developmental processes. The resolution of the processes depends on the questions of interest. As part of this chapter we introduce different descriptions of tissue morphogenesi s. In the simplest approximation tissue is a continuous domain and tissue expansion is described according to a predefined function of time (and possibly space). In a slightly more advanced version the expansion speed and direction of the tissue may depend on a signaling variable that evolves on the domain. Both versions will be referred to as "prescribed growth." Alternatively tissue can be regarded as incompressible fluid and can be described with Navier-Stokes equations. Local cell expansion, proliferation, and death are then incorporated by a source term. In other applications the cell boundaries may be important and cell-based models must be introduced. Finally, cells may move within the tissue, a process best described by agent-based models.