T-Cell antigen receptor-alpha chain transmembrane peptides: Correlaton between structure and function
T-Cell antigen receptor-alpha chain transmembrane peptides: Correlaton between structure and function
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DOI：
10.1007/s10989-006-9025-4
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发表时间：
2006-09-01
影响因子：
2.5
通讯作者：
Manolios, Nicholas
中科院分区：
文献类型：
--
作者：
Ali, Marina;Salam, Noeris K.;Manolios, Nicholas
Core peptide (CP) is a unique peptide derived from the transmembrane sequence of T cell antigen receptor (TCR)-alpha chain that is capable of inhibiting the immune response both in vitro and in animal models of T cell mediated inflammation. CP contains two basic amino acids (lysine and arginine) in its sequence. The presence of these charged residues interspersed between hydrophobic amino acids is important for function. Here in an attempt to Understand CP's biophysical properties leading to activity we have synthesized a number Or CP analogues and correlated their model structure With their biological activity. It became apparent that it is not only the charge of the amino acids but also the nature of the polar amino acids themselves and the topography and spacing between them by hydrophobic amino acids. creating a hydrophobic face, that are critical for CP function.
