The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
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DOI：
10.3389/fimmu.2019.00653
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发表时间：
2019-04
影响因子：
7.3
通讯作者：
Hao-Fan Wang;Sha-Sha Wang-Sha;Ya-Jie Tang;Yu Chen;Min Zheng;Ya-Ling Tang;Xin-hua Liang
中科院分区：
文献类型：
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作者：
Hao-Fan Wang;Sha-Sha Wang-Sha;Ya-Jie Tang;Yu Chen;Min Zheng;Ya-Ling Tang;Xin-hua Liang
人乳头瘤病毒（HPV）相关的头颈鳞状细胞癌（HNSCC）患者的预后明显较好，在临床、基因组、分子和免疫学方面与HPV阴性口咽鳞状细胞癌（OPSCC）不同，尤其具有免疫细胞高水平浸润和免疫抑制程度高的特点。本文将总结HPV阳性HNSCC的免疫逃避机制，分析宿主对HPV的各种免疫反应和丰富的浸润免疫细胞数量，并讨论HPV阳性HNSCC与宫颈癌的差异。对免疫景观的更深入了解将有助于免疫检查点肿瘤学中出现新概念，这可能是对现有概念的有价值的补充。
Patients with human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have remarkably better prognosis, which differs from HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) with respect to clinical, genomic, molecular, and immunological aspects, especially having the characteristics of high levels of immune cell infiltration and high degrees of immunosuppression. This review will summarize immune evasion mechanisms in HPV-positive HNSCC, analyze the host various immune responses to HPV and abundant numbers of infiltrating immune cell, and discuss the differences between HPV-positive HNSCC with cervical cancer. A deeper understanding of the immune landscape will help new concepts to emerge in immune-checkpoint oncology, which might be a valuable add-on to established concepts.