Correlation of findings in advanced MR techniques with global severity scales in patients with some grade of cognitive impairment
Correlation of findings in advanced MR techniques with global severity scales in patients with some grade of cognitive impairment
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DOI：
10.1179/174313209x405164
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发表时间：
2010-03-01
影响因子：
1.9
通讯作者：
Castillo, Julio
中科院分区：
文献类型：
--
作者：
Fayed, Nicolas;Davila, Jorge;Castillo, Julio
前言：先前对轻度认知障碍和阿尔茨海默病患者的一些研究已经探讨了1H磁共振波谱以及灌注和扩散加权成像结果的变化。这项工作的目的是将灌注和扩散加权成像和磁共振波谱的结果与认知障碍的两个全球严重程度量表：临床痴呆评分(CDR)和全球恶化程度量表(GDS)的结果进行关联。患者和方法：我们评估了87例不同级别的认知障碍患者(男性35例，女性52例；平均年龄70.2±8.5岁)。所有患者均由本院神经内科团队进行评估。他们应用了全球严重程度评分(CDR和GDS)，并将患者转介到我们的诊断成像部门进行脑磁共振成像研究，以及弥散和灌注加权成像和磁共振波谱研究。我们排除了有帕金森氏病、额颞叶痴呆、脑血管疾病、颅内肿瘤、脑积水、癫痫、酒精中毒和精神障碍的患者。在左侧枕叶皮质和扣带回后部进行磁共振波谱分析。代谢产物为N-乙酰天冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)和肌醇(Mi)。经弥散加权成像后，计算感兴趣区的海马区、颞叶白质、枕叶、顶叶、额叶和双侧扣带回后部的表观弥散系数值。在灌注加权成像中，我们计算了海马区、额叶灰质、枕叶、颞顶区、扣带回后部和躯体感觉皮质的相对脑血流量。采用Spearman系数分析各因素之间的相关性。结果：共发现阿尔茨海默病患者33例，轻度认知障碍患者54例。Spearman系数在CDR和GDS的相关性中具有统计学意义(R2=50.596，p
Introduction: Some previous studies in patients with mild cognitive impairment and Alzheimer's disease have probed changes in the results of 1 H magnetic resonance spectroscopy and perfusion-and diffusion-weighted imaging. The purpose of this work was to correlate the results of perfusion-and diffusion-weighted imaging and magnetic resonance spectroscopy with the results of two global severity scales in cognitive impairment: the clinical dementia rating (CDR) and the global deterioration scale (GDS).Patients and methods: We evaluated 87 patients with cognitive impairment of diverse grade (35 men and 52 women; mean age, 70.2 +/- 8.5 years old). All patients were evaluated by a neurological team in our hospital. They applied both global severity scales (CDR and GDS) and referred the patients to our diagnostic imaging department to make a cerebral magnetic resonance imaging study and studies of diffusion-and perfusion-weighted imaging and magnetic resonance spectroscopy. We excluded patients with history of Parkinson's disease, frontotemporal dementia, cerebrovascular disease, intracranial tumors, hydrocephaly, epilepsy, alcoholism and psychiatric disorders. Magnetic resonance spectroscopy was carried out in the left occipital cortex and in the posterior cingulate gyrus. The evaluated metabolites were N-acetylaspartate (NAA), choline (Cho), creatine (Cr) and myo-inositol (mI). After diffusion-weighted imaging, we calculated apparent diffusion coefficient values in the region of interest located in hippocampi, white matter of temporal lobes, occipital lobes, parietal lobes, frontal lobes and posterior cingulate gyrus of both hemispheres. In perfusion-weighted imaging, we calculated the relative cerebral blood volume in hippocampi, gray matter of frontal lobes, occipital lobes, temporoparietal regions, posterior cingulate gyri and somatic-sensorial cortex. We used Spearman coefficient to analyse the correlation among the different factors. Statistical analysis was made with SPSS 14 software.Results: We found 33 patients with Alzheimer's disease and 54 with mild cognitive impairment. The Spearman coefficient had statistical significance in the correlation of CDR and GDS (R-2=50.596, p