A Nanoscale Metal-Organic Framework to Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy.
A Nanoscale Metal-Organic Framework to Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy.
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DOI：
10.1002/anie.201911429
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发表时间：
2020-01-13
期刊：
影响因子：
--
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Ni K;Luo T;Lan G;Culbert A;Song Y;Wu T;Jiang X;Lin W
检查点阻断免疫疗法（CBI）唤醒宿主先天免疫系统并重新激活细胞毒性T细胞以在一些癌症患者中引起持久的应答。现在，一种阳离子纳米级金属有机框架，W-TBP，被用来促进肿瘤抗原呈递，使免疫原性光动力疗法（PDT）和促进树突状细胞（DC）的成熟。由双核WVI二级结构单元和光敏性5，10，15，20-四（对苯甲酰）卟啉（TBP）配体组成，阳离子W-TBP介导PDT释放肿瘤相关抗原并将免疫刺激性CpG寡脱氧核苷酸递送至DC。增强的抗原呈递与CBI协同作用以扩增和重振细胞毒性T细胞，从而在双侧乳腺癌模型中产生极好的抗癌功效和稳健的远位效应，其中肿瘤消退> 97%。
Checkpoint blockade immunotherapy (CBI) awakes a host innate immune system and reactivates cytotoxic T cells to elicit durable response in some cancer patients. Now, a cationic nanoscale metal–organic framework, W-TBP, is used to facilitate tumor antigen presentation by enabling immunogenic photodynamic therapy (PDT) and promoting the maturation of dendritic cells (DCs). Comprised of dinuclear WVI secondary building units and photosensitizing 5,10,15,20-tetra(p-benzoato)porphyrin (TBP) ligands, cationic W-TBP mediates PDT to release tumor associated antigens and delivers immunostimulatory CpG oligodeoxynucleotides to DCs. The enhanced antigen presentation synergizes with CBI to expand and reinvigorate cytotoxic T cells, leading to superb anticancer efficacy and robust abscopal effects with > 97% tumor regression in a bilateral breast cancer model.