Gene expression profile of aging and its retardation by caloric restriction
Gene expression profile of aging and its retardation by caloric restriction
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DOI：
10.1126/science.285.5432.1390
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发表时间：
1999-08-27
期刊：
影响因子：
56.9
通讯作者：
Prolla, TA
中科院分区：
文献类型：
--
作者：
Lee, CK;Klopp, RG;Prolla, TA
在小鼠骨骼肌中分析衰老过程的基因表达谱。使用代表6347个基因的高密度寡核苷酸阵列显示，衰老导致差异基因表达模式，表明显著的应激反应和代谢和生物合成基因的表达降低。大多数改变都被热量限制完全或部分阻止，这是已知的唯一延缓哺乳动物衰老的干预措施。热量限制动物的转录模式表明，热量限制通过引起代谢向增加蛋白质周转和减少大分子损伤的转变来延缓衰老过程。
The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and Lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals. Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.