The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection.
The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection.
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DOI：
10.1371/journal.pone.0000969
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发表时间：
2007-10-03
期刊：
影响因子：
3.7
通讯作者：
Clerici M
中科院分区：
文献类型：
--
作者：
Castelletti E;Lo Caputo S;Kuhn L;Borelli M;Gajardo J;Sinkala M;Trabattoni D;Kankasa C;Lauri E;Clivio A;Piacentini L;Bray DH;Aldrovandi GM;Thea DM;Veas F;Nebuloni M;Mazzotta F;Clerici M
CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propria (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model. CCL28 was augmented in breast milk (BM) plasma and saliva of HIV-infected and –exposed individuals; CCR3+ and CCR10+ B lymphocytes were increased in these same individuals. Additionally: 1) CCL28 concentration in BM was associated with longer survival in HIV vertically-infected children; and 2) gastro-intestinal mucosal IgA-ASC were significantly increased in VSV-immunized mice receiving CCL28. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28-including constructs should be considered in mucosal vaccines to prevent HIV infection of the gastro-intestinal MLP via modulation of IgA-ASC.
