New Casbane Diterpenoids from the Hainan Soft Coral Sinularia Species
New Casbane Diterpenoids from the Hainan Soft Coral Sinularia Species
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海南软珊瑚Sinularia 种的新卡班二萜类化合物
DOI：
10.1002/hlca.201400341
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发表时间：
2015-06-01
影响因子：
1.8
通讯作者：
Liu, Yonghong
中科院分区：
文献类型：
--
作者：
Yang, Bin;Huang, Jingxia;Liu, Yonghong
6个新的卡斯烷二萜化合物，分别命名为sinularcasbanesG-L（1-6，resp.）从软珊瑚Sinularia sp.中分离得到4个化合物，其结构经波谱分析，特别是2D-NMR和HR-ESI-MS确证，其结构经圆二色谱分析和文献数据比较确证。评价了化合物对10种人癌细胞系（H1975、U937、K562、BGC 823、MOLT-4、MCF-7、A549、HeLa、HL 60和Huh-7）的细胞毒性，结果显示没有活性。
Six new casbane diterpenoids, sinularcasbanes G-L (1-6, resp.) were isolated from the soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses, especially 2D-NMR and HR-ESI-MS. The configuration was confirmed by CD analyses and by comparison with data reported in the literature. The compounds were evaluated for cytotoxicity against ten human cancer cell lines (H1975, U937, K562, BGC823, MOLT-4, MCF-7, A549, HeLa, HL60, and Huh-7) and showed no activity.