AUTONOMIC NERVOUS-SYSTEM ACTIVITY IN IDIOPATHIC DILATED CARDIOMYOPATHY AND IN HYPERTROPHIC CARDIOMYOPATHY
AUTONOMIC NERVOUS-SYSTEM ACTIVITY IN IDIOPATHIC DILATED CARDIOMYOPATHY AND IN HYPERTROPHIC CARDIOMYOPATHY
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DOI：
10.1016/0002-9149(93)90547-p
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发表时间：
1993-06-01
影响因子：
2.8
通讯作者：
INOUE, H
中科院分区：
文献类型：
--
作者：
AJIKI, K;MURAKAWA, Y;INOUE, H
为评估心肌病患者的自主神经活动，采用24小时动态心电图对14例特发性扩张型心肌病（IDC）、15例肥厚型心肌病（HC）和18例健康受试者进行心率变异性分析。使用快速傅里叶变换计算夜间和白天的心率变异性，并在2个频率带宽下量化功率谱：0.00至0.15 Hz（低频功率[LF]）和0.15至0.50 Hz（高频功率[HF]）。Log（HF）被用作副交感神经活动的指数。Log（HF）显著降低，log（LF/HF）显著升高IDC。这些变化与射血分数有关。在HC中，低log（HF）和高log（LF/HF）仅在夜间被识别，并且这些变化与心肌肥厚的程度无关。我们的研究结果表明，HC在夜间的副交感神经活动和增强交感神经活动的衰减，也在IDC。通过分析心率变异性来评估自主神经失衡可能有助于了解心肌病的病理生理学。
To assess autonomic nervous activity in patients with cardiomyopathies, analysis of heart rate variability was performed using 24-hour ambulatory electrocardiograms in 14 patients with idiopathic dilated cardiomyopathy (IDC), 15 with hypertrophic cardiomyopathy (HC) and 18 healthy subjects. Heart rate variability during the night and daytime was calculated using fast-Fourier transform, and power spectra were quantified in 2 frequency bandwidths: 0.00 to 0.15 Hz (low-frequency power [LF]) and 0.15 to 0.50 Hz (high-frequency power [HF]. Log(HF) was used as an index of parasympathetic nervous activity. Log (HF) was significantly lower and log(LF/HF) was significantly higher IDC. These changes were related to ejection fraction. In HC, lower log(HF) and higher log(LF/HF) were recognized only during the night, and these changes were independent of the degree of myocardial hypertrophy. Our results indicated attenuation of parasympathetic activity and enhanced sympathetic activity in HC during the night, and also in IDC. Assessment of autonomic imbalance by analysis of heart rate variability may be useful for understanding the pathophysiology of cardiomyopathies.