Occurrence of increased arterial stiffness in a cohort of adult patients with type 1 diabetes mellitus when compared to normoglycemic controls.
Occurrence of increased arterial stiffness in a cohort of adult patients with type 1 diabetes mellitus when compared to normoglycemic controls.
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DOI：
10.1177/1932296814551982
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发表时间：
2015-01-01
影响因子：
5
通讯作者：
Mathew, Vivek
中科院分区：
文献类型：
--
作者：
George, Belinda;Bantwal, Ganapathi;Mathew, Vivek
1 型糖尿病患者心血管危险因素的患病率被低估。本研究旨在通过比较 1 型糖尿病患者与对照组的动脉僵硬度来评估心血管风险。包括 31 名 1 型糖尿病患者和 31 名年龄和性别匹配的对照者。使用非侵入性设备 Periscope 测量臂踝脉搏波速度 (ba-PWV)。与对照组 (1057.99 ± 95.8 cm/s) 相比，糖尿病患者的 ba-PWV (1177.09 ± 180.1 cm/s) 显着升高 (P = .003)。糖尿病患者的 ba-PWV 与年龄 (r = .43, P = .014)、心率 (r = .49, P = .005)、血压 (r = .65, P < .001) 和 LDL (r = .46, P = .008) 呈正相关。线性回归分析显示，糖尿病、年龄、收缩压 (SBP) 和 BMI 与 ba-PWV 独立相关 (R (2) = .589)。将糖尿病队列细分为 LDL 和 SBP 的五分位数时，在 LDL > 102 mg/dl（1187.8 cm/s 至 1364.9 cm/s，P = .09）和 SBP > 130 mmHg（1176.1 cm/s 至 1369.4 cm/s，P = .03）时，ba-PWV 显着增加。与健康对照相比，通过 ba-PWV 评估的 1 型糖尿病患者的动脉僵硬度显着增加，与传统的心血管危险因素无关。使用廉价且有效的方法对 SBP > 130 mmHg 和 LDL > 102 mg/dl 的患者进行动脉僵硬度早期筛查可能有助于识别心血管风险较高的患者。
The prevalence of cardiovascular risk factors among patients with type 1 diabetes is underestimated. This study was conducted to assess the cardiovascular risk by comparing arterial stiffness in type 1 diabetes with that of controls. Thirty-one type 1 diabetes patients and 31 age- and gender-matched controls were included. The brachial-ankle pulse wave velocity (ba-PWV) was measured using Periscope, a noninvasive device. The ba-PWV was found to be significantly elevated among the patients with diabetes (1177.09 ± 180.1 cm/s) when compared with the controls (1057.99 ± 95.8 cm/s) (P = .003). The ba-PWV showed positive correlation with age (r = .43, P = .014), heart rate (r = .49, P = .005), blood pressure (r = .65, P < .001), and LDL (r = .46, P = .008) among patients with diabetes. Linear regression analysis revealed that diabetes, age, systolic blood pressure (SBP), and BMI were independently associated with ba-PWV (R (2) = .589). On subdividing the diabetes cohort into quintiles for LDL and SBP, a substantial increase in ba-PWV was seen at LDL > 102 mg/dl (1187.8 cm/s to 1364.9 cm/s, P = .09) and SBP > 130 mmHg (1176.1 cm/s to 1369.4 cm/s, P = .03). Arterial stiffness as assessed by ba-PWV is significantly increased among patients with type 1 diabetes compared to healthy controls, independent of traditional cardiovascular risk factors. Early screening for arterial stiffness using a cheap and effective method among patients with SBP > 130 mmHg and LDL > 102 mg/dl may help identify those with heightened cardiovascular risk.