Myofibroblasts in Fibrotic Kidneys.
Myofibroblasts in Fibrotic Kidneys.
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DOI：
10.1007/s40139-013-0025-8
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发表时间：
2013-09-01
影响因子：
--
通讯作者：
Duffield JS
中科院分区：
文献类型：
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作者：
Nakagawa N;Duffield JS
肾小球和肾小球的纤维化是几乎所有慢性肾脏疾病的特征。纤维化与毛细血管的破坏、炎症和上皮损伤密切相关，上皮损伤进展为肾单位的损失和肾实质被瘢痕组织替代。了解形成瘢痕组织的肌成纤维细胞的起源和性质是开发肾脏疾病新疗法的核心。虽然体内的许多细胞谱系已被公认的标记物所定义，但肌成纤维细胞更难确定。最近的见解，从遗传命运映射和使用动态报告的细胞，使纤维状胶原蛋白在小鼠中已确定了更清晰的主要人口的肌成纤维细胞及其前体在肾脏。本文将探讨这些细胞在肾脏健康和疾病中的性质，以了解它们在肾脏疾病发病机制中的核心作用。
Fibrosis of the kidney glomerulus and interstitium are characteristic features of almost all chronic kidney diseases. Fibrosis is tightly associated with destruction of capillaries, inflammation, and epithelial injury which progresses to loss of nephrons, and replacement of kidney parenchyma with scar tissue. Understanding the origins and nature of the cells known as myofibroblasts that make scar tissue is central to development of new therapeutics for kidney disease. Whereas many cell lineages in the body have become defined by well-established markers, myofibroblasts have been much harder to identify with certainty. Recent insights from genetic fate mapping and the use of dynamic reporting of cells that make fibrillar collagen in mice have identified with greater clarity the major population of myofibroblasts and their precursors in the kidney. This review will explore the nature of these cells in health and disease of the kidney to underst and their central role in the pathogenesis of kidney disease.