Functional role of intrahypothalamic release of oxytocin and vasopressin: consequences and controversies.
Functional role of intrahypothalamic release of oxytocin and vasopressin: consequences and controversies.
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下丘脑内释放催产素和加压素的功能作用：后果和争议。
DOI：
10.1152/ajpendo.1995.268.4.e537
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Ludwig,M
中科院分区：
文献类型：
--
作者：
Ludwig,M
本文简要回顾了加压素（VP）和催产素（OT）释放到视上核（SON）和室旁核（PVN）的细胞外间隙，重点介绍了最近的数据，说明其核内释放的意义和潜在的功能后果。随着体外技术的使用，已经证明外源性OT的施用引起局部肽释放，并且在体内，这促进排乳反射。这些发现导致了内源性肽被释放到下丘脑核团的想法。微灌注技术已被用来监测动态反应不同的刺激核内OT和VP释放。很明显，OT的核内释放在生殖状态（分娩和哺乳）中起作用，VP和OT的核内释放参与生殖调节。本文讨论了1）核内释放肽的起源，2）引起下丘脑核内释放的刺激，3）核内VP和OT的功能，例如，局部形态的调节、反馈机制和同步化，以及在调节自主功能和行为中的可能作用。
This brief review of vasopressin (VP) and oxytocin (OT) release into the extracellular space of the supraoptic (SON) and paraventricular (PVN) nuclei focuses on recent data illustrating the significance of their intranuclear release and the potential functional consequences. With the use of in vitro techniques, it has been demonstrated that administration of exogenous OT causes local peptide release and that, in vivo, this facilitates the milk ejection reflex. These findings lead to the idea that endogenous peptides are released into the hypothalamic nuclei. Microperfusion techniques have been used to monitor the dynamics of intranuclear OT and VP release in response to distinct stimuli. It is clear that intranuclear release of OT plays a role during reproductive states (parturition and lactation) and that intranuclear release of VP and OT is involved in osmoregulation. This review discusses 1) the origin of the intranuclearly released peptides, 2) stimuli which cause release into the hypothalamic nuclei, and 3) the function of intranuclear VP and OT, e.g., regulation of local morphology, feedback mechanisms and synchronization, and the possible role in regulating autonomic function and behavior.