Electrocatalytic water-splitting for the controllable and sustainable synthesis of deuterated chemicals
Electrocatalytic water-splitting for the controllable and sustainable synthesis of deuterated chemicals
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电催化水分解用于氘代化学品的可控和可持续合成
DOI：
10.1016/j.scib.2020.09.016
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发表时间：
2021
期刊：
影响因子：
18.9
通讯作者：
Su Chenliang
中科院分区：
文献类型：
--
作者：
Zhang Bing;Qiu Chuntian;Wang Shan;Gao Hua;Yu Kunyi;Zhang Zhaofei;Ling Xiang;Ou Wei;Su Chenliang
串联水电解将通用原料转化为增值化学品，并结合制氢和原位利用，是解决电化学析氢和储存的经济挑战的一种有前途的方法。在此，我们提出了使用廉价且可重复使用的重水（D_2O）作为D源的卤化物的可控电催化氘化，用于在温和条件下制备有价值的D标记化学品和药物。这种高效和选择性的电化学氘化方法提供了一系列D标记化学品和药物的产率很高，具有优异的D结合能力。反应效率和选择性，即氘原子在不同卤素位置的精确取代，可以通过改变施加的电压来调节。结果表明，除了析氢之外，绿色、经济的电催化方法在生产增值精细化学品方面具有巨大潜力。
Tandem water electrolysis for the transformation of universal feedstock to value-added chemicals integrated with hydrogen generation and in situ utilization is a promising approach to address the economic challenges of electrochemical hydrogen evolution and storage.Herein, we present the controllable electrocatalytic deuteration of halides using inexpensive and reusable heavy water(D_2O) as a D-source for the preparation of valuable D-labelled chemicals and pharmaceuticals under mild conditions.This electrochemical deuteration method with high efficiency and selectivity furnishes a series of D-labelled chemicals and pharmaceuticals in high yields with excellent D-incorporation.The reaction efficiency and selectivity, that is, the precise substitution of deuterium atoms at different halogen positions, can be tuned by varying the applied voltages.The results show the great potential of green and economical electrocatalytic methods for producing value-added fine chemicals in addition to hydrogen evolution.