Shared Song Detector Neurons in Drosophila Male and Female Brains Drive Sex-Specific Behaviors
Shared Song Detector Neurons in Drosophila Male and Female Brains Drive Sex-Specific Behaviors
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DOI：
10.1016/j.cub.2019.08.008
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发表时间：
2019-10-07
期刊：
影响因子：
9.2
通讯作者：
Murthy, Mala
中科院分区：
文献类型：
--
作者：
Deutsch, David;Clemens, Jan;Murthy, Mala
对于同样的感官刺激，雄性和雌性往往会产生截然不同的反应。这些差异是如何产生的——在感觉处理的层面上还是在产生行为的回路上——在感觉模式上仍未得到很大的解决。我们在果蝇的声学通信系统中解决了这个问题。在求偶期间，雄性会发出随时间变化的歌声，而每一种性别都有特定的行为作为回应。我们在歌曲的各个方面描述了男性和女性的行为调整，并表明性别之间的特征调整是相似的，这表明性别共享的歌曲探测器驱动了不同的行为。然后，我们在果蝇的大脑中发现了被称为pC2的高级神经元，它被调整为一种模式的雄性歌曲的多个时间方面，并驱动性别特定的行为。因此，我们发现了位于感觉-运动界面的神经元，它们专门调谐到声音通信信号，灵活地将听觉感知与性别特异性行为反应联系起来。
Males and females often produce distinct responses to the same sensory stimuli. How such differences arise-at the level of sensory processing or in the circuits that generate behavior-remains largely unresolved across sensory modalities. We address this issue in the acoustic communication system of Drosophila. During courtship, males generate time-varying songs, and each sex responds with specific behaviors. We characterize male and female behavioral tuning for all aspects of song and show that feature tuning is similar between sexes, suggesting sex-shared song detectors drive divergent behaviors. We then identify higher-order neurons in the Drosophila brain, called pC2, that are tuned for multiple temporal aspects of one mode of the male's song and drive sex-specific behaviors. We thus uncover neurons that are specifically tuned to an acoustic communication signal and that reside at the sensory-motor interface, flexibly linking auditory perception with sex-specific behavioral responses.