Zinc deficiency enhances sensitivity to influenza A associated bacterial pneumonia in mice.
Zinc deficiency enhances sensitivity to influenza A associated bacterial pneumonia in mice.
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DOI：
10.14814/phy2.15902
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发表时间：
2024-01
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
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作者：
Although zinc deficiency (secondary to malnutrition) has long been considered an important contributor to morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials with supplemental zinc) for such a role in lower respiratory tract infection are somewhat ambiguous. In the current study, we provide the first preclinical evidence demonstrating that although diet‐induced acute zinc deficiency (Zn‐D: ~50% decrease) did not worsen infection induced by either influenza A (H1N1) or methicillin‐resistant staph aureus (MRSA), Zn‐D mice were sensitive to the injurious effects of superinfection of H1N1 with MRSA. Although the mechanism underlying the sensitivity of ZnD mice to combined H1N1/MRSA infection is unclear, it was noteworthy that this combination exacerbated lung injury as shown by lung epithelial injury markers (increased BAL protein) and decreased genes related to epithelial integrity in Zn‐D mice (surfactant protein C and secretoglobins family 1A member 1). As bacterial pneumonia accounts for 25%–50% of morbidity and mortality from influenza A infection, zinc deficiency may be an important pathology component of respiratory tract infections.
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影响因子：
168.9
作者：
Bhutta, Zulfiqar A.;Das, Jai K.;Black, Robert E.
通讯作者：
Black, Robert E.
DOI：
10.4049/jimmunol.2200261
发表时间：
2022-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
通讯作者：
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影响因子：
7.3
作者：
Gopal R;Lee B;McHugh KJ;Rich HE;Ramanan K;Mandalapu S;Clay ME;Seger PJ;Enelow RI;Manni ML;Robinson KM;Rangel-Moreno J;Alcorn JF
通讯作者：
Alcorn JF
影响因子：
9
作者：
Atkin-Smith GK;Duan M;Chen W;Poon IKH
通讯作者：
Poon IKH
影响因子：
8
作者：
Boudreault, Francis;Pinilla-Vera, Miguel;Baron, Rebecca M.
通讯作者：
Baron, Rebecca M.