Associations of long-term exposure to air pollution with prevalence of pulmonary nodules: A cross-sectional study in Shijiazhuang, China
Associations of long-term exposure to air pollution with prevalence of pulmonary nodules: A cross-sectional study in Shijiazhuang, China
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DOI：
10.1016/j.ecoenv.2023.115311
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发表时间：
2023-07-31
影响因子：
6.8
通讯作者：
Zhang，Helin
中科院分区：
文献类型：
--
作者：
Pei，Zijie;Wu，Mengqi;Zhang，Helin
对环境空气污染与肺结节患病率之间的关系尚缺乏全面的了解。我们的目的是调查环境空气污染物与肺结节患病率的关系。2018年4月1日至12月31日期间，共有9991人参加健康体检，其中3166人入选决赛。107名参与者被诊断为肺结节，3059名参与者被诊断为非肺结节（命名为对照组）。根据被试的居住或工作地址，采用经验贝叶斯Kriging模型对被试的个体暴露进行评价。通过胸部x线检查发现并诊断为肺结节。我们的研究结果表明，肺结节患病率与PM2.5（OR = 1.06, 95% CI: 1.02, 1.11）和O3（OR = 1.49, 95% CI: 1.35, 1.66）水平呈正相关。血小板计数（PLT）是与pm2.5暴露相关的肺结节的中介，中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）是与臭氧暴露相关的肺结节的中介。本研究提示，长期暴露于pm2.5和o3可能与肺结节患病率显著相关，而上述关联是由PLT、NLR和PLR介导的。
A complete understanding of the associations of ambient air pollution with prevalence of pulmonary nodule is lacking. We aimed to investigate the associations of ambient air pollutants with prevalence of pulmonary nodule. A total of 9991 health examination participants was enrolled and 3166 was elected in the final in Shijiazhuang between April 1st, 2018, and December 31st, 2018. 107 participants were diagnosed in pulmonary nodule while 3059 participants were diagnosed in non-pulmonary (named control). The individual exposure of participants was evaluation by Empirical Bayesian Kriging model according to their residential or work addresses. The pulmonary nodules were found and diagnosed by health examination through chest x-ray detection. Our results suggested that there were positive associations between prevalence of pulmonary nodules and PM2.5(OR = 1.06, 95% CI: 1.02, 1.11) as well as O3(OR = 1.49, 95% CI: 1.35, 1.66) levels. The platelet count (PLT) acted as the mediator of pulmonary nodules related with the PM2.5exposure, while the neutrophil-to-lymphocyte ratio (NLR) as well as platelet-to-lymphocyte ratio (PLR) were the mediators of pulmonary nodules related with the O3exposure. This study suggests that long-term exposure to PM2.5and O3may significantly associated with prevalence of pulmonary nodules, and the above associations are mediated by PLT, NLR and PLR.