Data supporting the role of Fyn in initiating myelination in the peripheral nervous system.
Data supporting the role of Fyn in initiating myelination in the peripheral nervous system.
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DOI：
10.1016/j.dib.2016.03.096
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发表时间：
2016-06
期刊：
影响因子：
1.2
通讯作者：
Yamauchi J
中科院分区：
文献类型：
--
作者：
Miyamoto Y;Tamano M;Torii T;Kawahara K;Nakamura K;Tanoue A;Takada S;Yamauchi J
已经产生了在神经胶质细胞酸性蛋白启动子控制下表达活性Fyn酪氨酸激酶的转基因小鼠。该启动子在周围神经系统（PNS）髓鞘形成的起始阶段诱导蛋白质表达。“Fyn对细胞粘连蛋白-1的磷酸化是髓鞘形成的起始和发育过程中髓鞘形成的程度所需的（Yamauchi等人，2015）"。本文提供了转基因小鼠髓鞘形成相关蛋白标记物和髓鞘超微结构的数据。
Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous system (PNS) “Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development (Yamauchi et al., 2015)”. Herein we provide the data regarding myelination-related protein markers and myelin ultrastructure in transgenic mice.