Polymyxin derivatives as broad-spectrum antibiotic agents
Polymyxin derivatives as broad-spectrum antibiotic agents
复制标题
作为广谱抗生素的多粘菌素衍生物
DOI：
10.1039/c9cc06908a
复制
发表时间：
2019
影响因子：
4.9
通讯作者：
Cai, Jianfeng
中科院分区：
文献类型：
--
作者：
Su, Ma;Wang, Minghui;Hong, Yuzhu;Nimmagadda, Alekhya;Shen, Ning;Shi, Yan;Gao, Ruixuan;Zhang, En;Cao, Chuanhai;Cai, Jianfeng
我们设计了几个具有广谱抗菌活性的多粘菌素衍生物。先导化合物P1能迅速破坏细菌细胞膜而不产生耐药性，抑制大肠杆菌形成生物膜。大肠杆菌，并在MRSA感染的大腿负荷小鼠模型中表现出优异的体内活性。
We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.