Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study.
Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study.
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DOI：
10.2337/dc11-1641
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发表时间：
2012-03
期刊：
影响因子：
16.2
通讯作者：
HAPO Study Cooperative Research Group
中科院分区：
文献类型：
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作者：
Sacks DA;Hadden DR;Maresh M;Deerochanawong C;Dyer AR;Metzger BE;Lowe LP;Coustan DR;Hod M;Oats JJ;Persson B;Trimble ER;HAPO Study Cooperative Research Group
采用新的国际糖尿病与妊娠研究组协会（IADPSG）标准，报告参与高血压和不良妊娠结局（HAPO）研究的15家中心的妊娠期糖尿病（GDM）频率。所有参与者在妊娠24至32周期间接受了75 g口服葡萄糖耐量试验。GDM采用IADPSG标准（一个或多个空腹、1小时或2小时血糖浓度分别等于或大于阈值5.1、10.0或8.5 mmol/L）进行回顾性分类。GDM的总体发生率为17.8%（范围9.3-25.5%）。血糖测量值符合诊断阈值的中心间差异显著。尽管GDM的新诊断标准在全球范围内适用，但在GDM的频率和空腹、1小时和2小时血糖水平的相对诊断重要性方面，中心与中心之间存在差异。这可能会影响用于诊断GDM的策略。
To report frequencies of gestational diabetes mellitus (GDM) among the 15 centers that participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study using the new International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria. All participants underwent a 75-g oral glucose tolerance test between 24 and 32 weeks’ gestation. GDM was retrospectively classified using the IADPSG criteria (one or more fasting, 1-h, or 2-h plasma glucose concentrations equal to or greater than threshold values of 5.1, 10.0, or 8.5 mmol/L, respectively). Overall frequency of GDM was 17.8% (range 9.3–25.5%). There was substantial center-to-center variation in which glucose measures met diagnostic thresholds. Although the new diagnostic criteria for GDM apply globally, center-to-center differences occur in GDM frequency and relative diagnostic importance of fasting, 1-h, and 2-h glucose levels. This may impact strategies used for the diagnosis of GDM.