Plasma fetuin-A concentrations in young and older high- and low-active men
Plasma fetuin-A concentrations in young and older high- and low-active men
复制标题
DOI：
10.1016/j.metabol.2010.01.026
复制
发表时间：
2011-02-01
影响因子：
9.8
通讯作者：
Witkowski, Sarah
中科院分区：
文献类型：
--
作者：
Jenkins, Nathan T.;McKenzie, Jennifer A.;Witkowski, Sarah
胎儿素a是一种肝源性因子，可能在胰岛素抵抗和年龄相关慢性疾病（如2型糖尿病和心血管[CV]疾病）中发挥作用。经常锻炼可以改善心血管风险和胰岛素敏感性；然而，目前尚不清楚是否。长期运动训练与胎儿素a的循环水平有关。因此，本研究考察了血浆胎儿素a水平是否与男性年龄和慢性体力活动有关。我们假设，在年轻和老年男性中，慢性体育活动可能与较低的血浆胎儿素a水平有关。在健康的高活性（HI）和低活性（LO）年轻男性（HI, n = 7； LO, n = 8）和老年男性（HI, n = 12， LO, n = 11）中，我们测定了心肺适能（最大摄氧量）、血浆胎蛋白a水平、血浆胰岛素、胰岛素抵抗（胰岛素抵抗的稳态模型评估）和心血管疾病的标准危险因素。各组的身体质量指数相匹配。与HI患者相比，年轻和老年LO患者的胎儿素a明显较高（接近20%），胎儿素a与最大摄氧量呈负相关（r = -0.40， P= 0.014）。血浆胎儿素a水平与老年人胰岛素水平（r = -0.34， P= 0.052）和胰岛素抵抗稳态模型评估（r = 0.33， P= 0.058）呈显著相关。在年轻的参与者中，胎儿素a与血压和胆固醇有关。这些结果表明，低水平的胎儿素a与心肺健康和许多传统的心血管和代谢性疾病危险因素有关，与年龄和体重指数无关。因此，维持低水平的循环胎儿素a可能是促进胰岛素敏感性增强的一种新机制。(C) 2011爱思唯尔公司版权所有。
Fetuin-A is a liver-derived factor that may play a role in insulin resistance and age-related chronic diseases (eg, type 2 diabetes mellitus and cardiovascular [CV] disease). Regular exercise improves CV risk and insulin sensitivity; however, it is unknown whether. chronic exercise training is related to circulating levels of fetuin-A. Therefore, this study examined whether plasma fetuin-A levels were related to age and chronic physical activity in men. We hypothesized that chronic physical activity would be related to lower plasma fetuin-A levels in younger and older men. In healthy high-active (HI) and low-active (LO) young (HI, n = 7; LO, n = 8) and older (HI, n = 12, LO, n = 11) men, we determined cardiorespiratory fitness (maximal oxygen uptake), plasma fetuin-A levels, plasma insulin, insulin resistance (homeostasis model assessment of insulin resistance), and the standard risk factors for CV disease. Groups were matched for body mass index. Fetuin-A was significantly higher (similar to 20%) in both young and older LO men compared with their HI counterparts, and fetuin-A was inversely related to maximal oxygen uptake (r = -0.40, P=.014). Plasma fetuin-A levels showed trends to be significantly correlated with insulin (r = -0.34, P=.052) and homeostasis model assessment of insulin resistance (r = 0.33, P=.058) in the older individuals. In younger participants, fetuin-A was related to blood pressure and cholesterol measures. These results indicate that low levels of fetuin-A are related to cardiorespiratory fitness and a number of conventional CV and metabolic disease risk factors independent of age and body mass index. Therefore, the maintenance of low levels of circulating fetuin-A may be a novel mechanism contributing to enhanced insulin sensitivity with regular physical activity. (C) 2011 Elsevier Inc. All rights reserved.