Cytochrome P450 2C9-CYP2C9.

Cytochrome P450 2C9-CYP2C9.
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DOI:
10.1097/fpc.0b013e3283349e84
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发表时间:
2010-04
影响因子:
2.6
通讯作者:
Altman RB
Altman RB
中科院分区:
医学4区
文献类型:
--
作者:
Van Booven D;Marsh S;McLeod H;Carrillo MW;Sangkuhl K;Klein TE;Altman RB

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细胞色素P450是细胞色素P450的I相代谢酶,在异源化合物和内源化合物的氧化过程中都起着重要作用。Gray等人在[1]中发现,在染色体10q24的500kb区域内聚集的几个CYP2C基因中,有一种是CYP2C9。该簇由四个按顺序排列的基因组成
CYP2C9 is a phase I drug-metabolizing cytochrome P450 (CYP450) enzyme isoform that plays a major role in the oxidation of both xenobiotic and endogenous compounds. Gray et al.[1] identified CYP2C9 as one of several CYP2C genes clustered in a 500 kb region on chromosome 10q24. The cluster comprises four genes arranged in the order