Sleep-disordered breathing: effects on brain structure and function.
Sleep-disordered breathing: effects on brain structure and function.
复制标题
DOI：
10.1016/j.resp.2013.04.021
复制
发表时间：
2013-09-15
影响因子：
2.3
通讯作者：
Macey, Paul M.
中科院分区：
文献类型：
--
作者：
Harper, Ronald M.;Kumar, Rajesh;Ogren, Jennifer A.;Macey, Paul M.
关键词：
睡眠呼吸障碍伴有神经损伤，其影响广泛的生理系统，包括用于感测化学感受和气流、驱动呼吸肌肉组织、用于协调呼吸模式的定时电路以及血压机制与呼吸的整合的过程。这种损害也发生在调节情绪和情绪的区域，以及调节记忆和认知功能的区域，并出现在重要的血糖控制过程中。受损的结构包括参与激素释放和主要神经递质作用的大脑区域，包括那些在抑郁症中发挥作用的区域。损伤反映在一系列结构磁共振程序中，并且还表现为介导重要自主神经和呼吸功能的脑区域中的诱发活动的功能扭曲。损伤优先是单侧的，包括轴突投射;损伤的不对称性对交感神经放电和心律失常的潜在后果提出了独特的担忧。睡眠呼吸障碍应被视为一种包括中枢神经系统损伤和功能受损的疾病;损伤的潜在过程仍不清楚。
Sleep-disordered breathing is accompanied by neural injury that affects a wide range of physiological systems which include processes for sensing chemoreception and airflow, driving respiratory musculature, timing circuitry for coordination of breathing patterning, and integration of blood pressure mechanisms with respiration. The damage also occurs in regions mediating emotion and mood, as well as areas regulating memory and cognitive functioning, and appears in structures that serve significant glycemic control processes. The injured structures include brain areas involved in hormone release and action of major neurotransmitters, including those playing a role in depression. The injury is reflected in a range of structural magnetic resonance procedures, and also appears as functional distortions of evoked activity in brain areas mediating vital autonomic and breathing functions. The damage is preferentially unilateral, and includes axonal projections; the asymmetry of the injury poses unique concerns for sympathetic discharge and potential consequences for arrhythmia. Sleep-disordered breathing should be viewed as a condition that includes central nervous system injury and impaired function; the processes underlying injury remain unclear.
登录
查看更多内容
影响因子：
15.8
作者：
Halbower AC;Degaonkar M;Barker PB;Earley CJ;Marcus CL;Smith PL;Prahme MC;Mahone EM
通讯作者：
Mahone EM
影响因子：
4.7
作者：
Gozal, D;Row, BW;Brittian, KR
通讯作者：
Brittian, KR
影响因子：
24
作者：
Hanninen, SA;Darling, PB;Keith, ME
通讯作者：
Keith, ME
影响因子：
3.1
作者：
Chen, ML;Witmans, MB;Keens, TG
通讯作者：
Keens, TG
影响因子：
37.8
作者：
Gottlieb DJ;Yenokyan G;Newman AB;O'Connor GT;Punjabi NM;Quan SF;Redline S;Resnick HE;Tong EK;Diener-West M;Shahar E
通讯作者：
Shahar E