Effect of dopamine receptor-related compounds on naive common marmosets for auditory steady-state response
Effect of dopamine receptor-related compounds on naive common marmosets for auditory steady-state response
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多巴胺受体相关化合物对幼稚普通狨猴听觉稳态反应的影响
DOI：
10.1152/jn.00147.2022
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发表时间：
2022
影响因子：
2.5
通讯作者：
Ikeda Kazuhito
中科院分区：
文献类型：
--
作者：
Iwamura Yoshihiro;Nakayama Tatsuo;Matsumoto Atsushi;Ogi Yuji;Yamaguchi Masataka;Kobayashi Atsushi;Matsumoto Kenji;Katsura Yasunori;Konoike Naho;Nakamura Katsuki;Ikeda Kazuhito
研究精神分裂症患者听觉稳态反应(ASSR)的异常及抗精神病药物对ASSR的影响。据推测，药物不会直接影响ASSR，因为它的异常与精神分裂症有关。因此，为了研究药物对ASSR的直接影响，我们建立了处于幼稚状态的常见绒猴的ASSR评估体系。刺激多巴胺D_1受体(SKF-81297，2 mg/kg ip)可显著增加40 Hz的诱发功率(EP)。在20、30、40和80赫兹，锁相因子(PLF)显著增加。然而，多巴胺D_1受体拮抗剂(SCH-39166，0.3 mg/kg ip)可显著降低30赫兹的EP和PLF。刺激多巴胺D2受体(1 mg/kg im)在所有频率下均有增加EP和诱导功率(IP)的趋势，且在30 Hz ip时差异有统计学意义。PLF在所有频率下均无变化。此外，多巴胺D2受体阻断剂(拉氯必利，3 mg/kg ip)可降低30 Hz时的EP和PLF。皮下注射5-羟色胺-多巴胺拮抗剂利培酮(0.3 mg/kg)有增加IP和降低PLF的趋势，但不显著。综上所述，使用天真的非人类灵长类动物来比较药物对ASSR作用模式的差异是可能的。新与诺特沃特我们测量了多巴胺受体相关化合物对绒猴ASSR的影响。刺激D_1受体后，相锁定因子(PLF)和诱发功率(EP)增加，诱导功率(IP)降低。刺激D2受体可增加IP。D_1和D_2受体阻断剂可降低30赫兹的PLF和EP。通过给幼稚的绒猴注射抗精神病药物，评估了与精神障碍有关的各种药物的不同作用模式。
Abnormalities of auditory steady-state responses (ASSRs) and the effects of antipsychotic drugs on ASSRs have been investigated in patients with schizophrenia. It is presumed that drugs do not directly affect ASSRs because its abnormalities are associated with schizophrenia. Therefore, to investigate the direct effect of drugs on ASSRs, we established an ASSR evaluation system for common marmosets in a naïve state. Dopamine D1 receptor stimulation (SKF-81297, 2 mg/kg ip) significantly increased evoked power (EP) at 40 Hz. The phase locking factor (PLF) was increased significantly at 20, 30, 40, and 80 Hz. However, administration of a dopamine D1 receptor antagonist (SCH-39166, 0.3 mg/kg ip) resulted in a significant decrease in EP and PLF at 30 Hz. Dopamine D2 receptor stimulation (quinpirole, 1 mg/kg im) tended to increase EP and induced power (IP) at all frequencies, and a significant difference was observed at 30 Hz IP. There was no change in PLF at all frequencies. In addition, dopamine D2 receptor blockade (raclopride, 3 mg/kg ip) reduced EP and PLF at 30 Hz. Subcutaneous administration of the serotonin dopamine antagonist, risperidone (0.3 mg/kg), tended to increase IP and decrease PLF, but not significantly. Taken together, it is possible to compare the differences in the mode of action of drugs on ASSRs using naïve nonhuman primates.NEW & NOTEWORTHYWe measured the effects of dopamine receptor-related compounds on ASSR in marmosets. D1 receptor stimulation increased the phase locking factor (PLF) and evoked power (EP), and reduced the induced power (IP). D2 receptor stimulation increased the IP. D1 and D2 receptor blockers reduced the PLF and EP at 30 Hz. Different modes of action of various drugs related to psychiatric disorders were evaluated by administering antipsychotic drugs to naïve marmosets.