Ion channel regulation by calmodulin binding
Ion channel regulation by calmodulin binding
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DOI：
10.1016/0014-5793(94)00782-9
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发表时间：
1994-08
期刊：
影响因子：
3.5
通讯作者：
Y. Saimi;C. Kung
中科院分区：
文献类型：
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作者：
Y. Saimi;C. Kung
虽然许多离子通道是由磷酸化调节的，但越来越多的证据表明它们也可以由Ca2+-钙调蛋白调节，显然是通过直接结合。在某些情况下，这种绑定激活通道；在其他情况下，它调节通道活动。这些现象已经在草履虫、果蝇、脊椎动物的光感受器和嗅觉感受器以及ryanodine受体Ca2+释放通道中被记录。此外，草履虫中钙调素突变体的研究表明，钙调素基因的两组突变明显分布在两部分，导致相反的行为和电生理表型。这些结果表明，钙调蛋白的n叶与一类离子通道蛋白特异性相互作用，c叶与另一类离子通道蛋白特异性相互作用。
While many ion channels are modulated by phosphorylation, there is growing evidence that they can also be regulated by Ca2+-calmodulin, apparently through direct binding. In some cases, this binding activates channels; in others, it modulates channel activities. These phenomena have been documented inParamecium, inDrosophila, in vertebrate photoreceptors and olfactory receptors, as well as in ryanodine receptor Ca2+-release channels. Furthermore, studies on calmodulin mutants inParameciumhave shown a clear bipartite distribution of two groups of mutations in the calmodulin gene that lead to opposite behavioral and electrophysiological phenotypes. These results indicate that the N-lobe of calmodulin specifically interacts with one class of ion-channel proteins and the C-lobe with another.