Cortical activation states in sleep and anesthesia. I: Cardio-respiratory effects
Cortical activation states in sleep and anesthesia. I: Cardio-respiratory effects
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DOI：
10.1016/s0034-5687(98)00018-8
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发表时间：
1998-04-01
期刊：
影响因子：
--
通讯作者：
Milson, WK
中科院分区：
文献类型：
--
作者：
Hunter, JD;Milson, WK
在轻度氨基甲酸乙酯麻醉下，动物循环通过EEG活动模式，这些模式表面上看起来像未麻醉动物的清醒、轻度睡眠和慢波睡眠模式（分别为状态I、II和III）。本研究质疑是否相似的皮质活动模式在麻醉和未麻醉的金绒面地松鼠代表类似的状态，在心肺功能。睡眠对呼吸频率和通气量有很强的负面影响，但对潮气量的影响不太一致。当在具有相似皮质活动的状态之间切换时，乌拉坦麻醉的动物表现出完全相同的呼吸变量变化。心血管功能也受到唤醒状态的影响;当动物从清醒进入睡眠时，心率下降，变异性显著增加。虽然乌拉坦麻醉大大增加了心率，消除了呼吸性窦性心律失常，但心率的状态依赖性变化仍然很明显。总体而言，在氨基甲酸乙酯麻醉下观察到的状态在其对心肺功能的影响方面模仿睡眠/觉醒。(C)1998 Elsevier Science B. V.保留所有权利。
Under light urethane anesthesia, animals cycle through patterns of EEG activity which superficially appear like waking, light sleep and slow-wave sleep patterns (States I, II and III, respectively) in unanesthetized animals. The present study questioned whether similar cortical activity patterns in anesthetized and unanesthetized golden mantled ground squirrels represented analogous states in terms of cardiorespiratory function. Sleep exerted a strong negative influence on breathing frequency and ventilation, but had less consistent effects on tidal volume. Urethane-anesthetized animals demonstrated exactly the same alterations in respiratory variables when switching between states with similar cortical activity. Cardiovascular function was also affected by arousal state; heart rate decreased and variation increased significantly as animals moved from wake into sleep. Although urethane anesthesia greatly increased heart rate and abolished respiratory sinus arrhythmia, state-dependent changes in heart rate were still evident. Overall, the states observed under urethane anesthesia mimicked sleep/wake in terms of their effect on cardio-respiratory function. (C) 1998 Elsevier Science B.V. All rights reserved.