Derivation of Clinically Applicable Schwann Cells from Bone Marrow Stromal Cells for Neural Repair and Regeneration
Derivation of Clinically Applicable Schwann Cells from Bone Marrow Stromal Cells for Neural Repair and Regeneration
复制标题
从骨髓基质细胞衍生出临床适用的雪旺细胞，用于神经修复和再生。
DOI：
10.2174/187152711795563930
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发表时间：
2011-06-01
影响因子：
3
通讯作者：
Shum, Daisy K. Y.
中科院分区：
文献类型：
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作者：
Cai, Sa;Shea, Graham K. H.;Shum, Daisy K. Y.
雪旺细胞对周围神经损伤后的组织修复、轴突再生和髓鞘再生至关重要。中枢神经系统(CNS)中缺乏雪旺细胞或类似的细胞类型可能会限制中枢神经系统的再生能力。因此，人们对间充质干细胞(MSCs)诱导分化为雪旺细胞表型的潜力进行了研究。本文综述了从骨髓间充质干细胞分化为雪旺细胞样细胞的方法，以及每种方法的优点和局限性。讨论了与衍生雪旺细胞表型的不稳定性、移植中衍生细胞的凋亡以及无法准确预测移植后细胞行为的相关问题。最后，我们建议有必要进一步阐明雪旺细胞分化的生物学机制及其来源于MSC的信号，以解决这些障碍，并使MSC来源的雪旺细胞移植成为治疗中枢神经系统损伤的一种策略。
Schwann cells are critically important for tissue repair, axonal regrowth and remyelination following injury to peripheral nerves. The absence of Schwann cells or an equivalent cell type in the central nervous system (CNS) may limit the regeneration capacity of the CNS. Mesenchymal stem cells (MSCs) have therefore been investigated for their potential to be induced to develop a Schwann cell phenotype. The methods for derivation of Schwann cell-like cells from MSCs and the benefits and limitations of each of these methods are presented in this review. Issues related to instability of the derived Schwann cell phenotype, apoptosis of derived cells in transplants, and the inability to predict with confidence how the cells will behave after transplantation are discussed. Finally, we suggest the need for further elucidation of the biology of Schwann cell differentiation and the signals for their derivation from MSC, in order to resolve these obstacles and to enable transplantation of MSC-derived Schwann cells as a therapeutic strategy in CNS injury.