Age and renal prostaglandin inhibition during exercise and heat stress.
Age and renal prostaglandin inhibition during exercise and heat stress.
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运动和热应激期间的年龄和肾前列腺素抑制。
DOI：
10.1152/jappl.1999.86.6.1936
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Kenney,WL
中科院分区：
文献类型：
--
作者：
Farquhar,WB;Kenney,WL
衰老与许多生理变化相关，这些变化可能导致肾脏在更大程度上依赖于血管舒张PG来实现正常功能。急性运动已被证明会引起肾血管收缩，这可能是由血管舒张PG部分缓冲。为了确定老年人运动过程中肾脏PG的相对重要性，我们比较了PG抑制剂布洛芬（1.2 g/天，持续3天）与安慰剂对照组在炎热（36°C）下跑步机运动（最大耗氧量约57%）期间对8名年轻（24 ± 2岁）和8名老年（64 ± 2岁）女性的肾脏影响。这种非处方剂量的布洛芬降低了肾PG（即，PGE_2排泄量增加47%（P< 0.05）。在高温下的急性运动导致两个年龄组的肾小球滤过率、肾血流量和钠排泄显著下降。PG抑制与尿量和自由水清除率的更大减少相关（P< 0.05）。肾小球滤过率或肾血流量没有药物相关的下降。我们的结论是，PG抑制只有适度的影响，在运动过程中的肾功能。此外，缺乏血液动力学变化与PG抑制表明，健康的水分充足的老年妇女是不是在肾PG依赖性状态。
Aging is associated with a number of physiological changes that may cause the kidney to rely to a greater extent on vasodilatory PGs for normal functioning. Acute exercise has been shown to cause renal vasoconstriction that may be partially buffered by vasodilatory PGs. To determine the relative importance of renal PGs during exercise in older adults, we compared the renal effects of the PG inhibitor ibuprofen (1.2 g/day for 3 days) vs. a placebo control in a cohort of eight younger (24 ± 2 yr) and eight older (64 ± 2 yr) women during treadmill exercise (∼57% maximal oxygen consumption) in the heat (36°C). This over-the-counter dose of ibuprofen reduced renal PG (i.e., PGE2) excretion by 47% (P< 0.05). Acute exercise in the heat caused dramatic decreases in glomerular filtration rate, renal blood flow, and sodium excretion in both age groups. PG inhibition was associated with greater decreases in urine production and free water clearance (P< 0.05). There were no drug-related declines in glomerular filtration rate or renal blood flow. We conclude that PG inhibition has only modest effects on renal function during exercise. Also, the lack of hemodynamic changes with PG inhibition indicates that healthy well-hydrated older women are not in a renal PG-dependent state.