Tumor indicating normal tissue could be a new source of diagnostic and prognostic markers for prostate cancer.
Tumor indicating normal tissue could be a new source of diagnostic and prognostic markers for prostate cancer.
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DOI：
10.1517/17530059.2011.540009
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Bergh, Anders
中科院分区：
文献类型：
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作者：
Halin, Sofia;Hammarsten, Peter;Bergh, Anders
前列腺癌是一种常见的多灶性疾病，但现有的诊断方法并不令人满意。大多数肿瘤是低恶性潜能的，而其他肿瘤是高度侵袭性的。目前，成像不能用于引导组织活检安全地朝向最具侵袭性的肿瘤。为了解决这个问题，需要进行多针活检。活检通常只包含正常的前列腺组织，即使肿瘤被取样，也不知道器官中是否存在更具侵袭性的癌症。如果正常组织的变化表明肿瘤的存在和性质，这些信息可用于改善前列腺癌的诊断和治疗。本综述涵盖的领域：目前的证据表明，肿瘤相邻的形态正常的前列腺组织是不完全正常的审查，并认为这种组织，命名为肿瘤指示正常组织（TINT）的作者，可以用来诊断前列腺癌。什么读者将获得：读者将理解，肿瘤需要影响其周围环境以便生长和转移，并且正常前列腺组织因此被癌症的存在和性质着色，并且该知识可用于开发新的诊断和治疗方法。TINT的变化可能，当更严格的定义和验证，被用来诊断和预测前列腺癌。
IMPORTANCE OF THE FIELD: Prostate cancer is a common and multifocal disease but the diagnostic methods available are unsatisfactory. Most tumors present are of low malignant potential, whereas others are highly aggressive. At present, imaging cannot be used to guide tissue biopsies safely towards the most aggressive tumor present. To handle this problem multiple needle biopsies are taken. The biopsies often contain only normal prostate tissue, and even if the tumor is sampled it is not known whether a more aggressive cancer is present elsewhere in the organ. If changes in the normal tissue indicate the presence and nature of tumors, this information could be used to improve diagnostics and prognostics of prostate cancer.AREAS COVERED IN THIS REVIEW: Current evidence that the tumor-adjacent morphologically normal prostate tissue is not completely normal is reviewed, and that this tissue, named tumor indicating normal tissue (TINT) by the authors, can be used to diagnose prostate cancer.WHAT THE READER WILL GAIN: The reader will understand that tumors need to affect their surroundings in order to grow and metastasize and that the normal prostate tissue is therefore tinted by the presence and nature of cancer and that this knowledge can be used to develop new diagnostic and prognostic markers.TAKE HOME MESSAGE: TINT changes could probably, when more rigorously defined and validated, be used to diagnose and prognosticate prostate cancer.