Coronary aneurysms in patients with autosomal dominant polycystic kidney disease.
Coronary aneurysms in patients with autosomal dominant polycystic kidney disease.
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常染色体显性多囊肾病患者的冠状动脉瘤。
DOI：
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发表时间：
1998
影响因子：
13.6
通讯作者：
G. Nyberg
中科院分区：
文献类型：
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作者：
H. Hadimeri;C. Lamm;G. Nyberg
常染色体显性遗传性多囊肾病（ADPKD）患者颅内动脉瘤的风险增加。关于其他部位动脉瘤的报告尚未得出结论。本研究旨在调查冠状动脉瘤的患病率。30例ADPKD患者根据临床指征接受了冠状动脉造影，其中15例为肾移植后。对于每个ADPKD患者，对照组患者被确定为终末期肾病，通过冠状动脉造影进行调查，并在年龄，性别和移植时间相关性方面进行匹配。检索所有血管造影片并重新评价动脉瘤（定义为动脉直径增加50%或以上）以及不符合该标准的病理性扩张。在4名ADPKD患者和2名对照受试者中检测到动脉瘤。另外5名ADPKD患者，但没有对照组，有轻微的扩张。1例ADPKD患者有夹层主动脉瘤，另1例在旁路手术期间死于主动脉夹层。这项研究增加了ADPKD患者颅外动脉瘤风险增加的证据。
Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased risk of intracranial aneurysms. Reports on arterial aneurysms in other locations have not been conclusive. The present study was initiated to investigate the prevalence of coronary aneurysms. Thirty ADPKD patients who had undergone coronary angiography on clinical indication were identified, 15 after renal transplantation. For each ADPKD patient, a control patient was identified with end-stage renal disease, investigated by coronary angiography, and matched for age, sex, and time relation to transplantation. All angiograms were retrieved and reevaluated with respect to aneurysms, defined as an increase in artery diameter by 50% or more, as well as to pathologic ectasias not fulfilling this criterion. Aneurysms were detected in four ADPKD patients and two control subjects. Five more ADPKD patients, but none of the control subjects, had minor ectasias. One ADPKD patient had a dissecting aortic aneurysm, and another died of aortic dissection during bypass surgery. This study adds to the evidence of an increased risk of extracranial aneurysms in ADPKD patients.
DOI：
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发表时间：
1993-06
期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
--
作者：
John Huston;Vicente E. Torres;P. Sulivan;K. Offord;D. Wiebers
通讯作者：
John Huston;Vicente E. Torres;P. Sulivan;K. Offord;D. Wiebers
多囊蛋白在人体组织和培养细胞中的免疫定位。
DOI：
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发表时间：
1996
期刊：
Proceedings of the Association of American Physicians.
影响因子：
--
作者：
Griffin,MD;Torres,VE;Grande,JP;Kumar,R
通讯作者：
Kumar,R