The UCLA Longitudinal Study of Neurocognitive Outcomes Following Mild Pediatric Traumatic Brain Injury
The UCLA Longitudinal Study of Neurocognitive Outcomes Following Mild Pediatric Traumatic Brain Injury
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DOI：
10.1017/s1355617711000907
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发表时间：
2011-09-01
影响因子：
2.6
通讯作者：
Asarnow, Robert F.
中科院分区：
文献类型：
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作者：
Babikian, Talin;Satz, Paul;Asarnow, Robert F.
对儿童轻微、不复杂的创伤性脑损伤(TBI)后神经认知结果的综合审查表明，特别是在方法上严格的研究中，对神经认知的影响微乎其微。在这项研究中，我们报告了与两个人口学上匹配的对照组(其他损伤：11=94和非损伤：It=106)相比，在大样本轻度脑损伤(n=124，受伤时年龄8-17岁)中，纵向(损伤后1、6和12个月)神经认知功能的四个领域的结果。在考虑了年龄和父母教育后，在10项神经认知测试中，有7项出现了显著的组主效应。然而，这些差异并不是脑损伤样本所独有的，而是在脑损伤和其他损伤组之间发现的，相对于非损伤组，这表明了一般的损伤效应。影响主要是在测量记忆、精神运动处理速度和语言的领域内。这是迄今为止对儿童轻度脑外伤离散时间点的神经认知结果进行的最大规模的纵向研究。在控制损伤前因素时，没有证据表明与另一损伤对照组相比，这组患者存在长期的神经认知障碍。在评估轻度脑外伤对认知的影响的背景下，讨论了纵向分析和使用适当的对照组的重要性。(ENS，2011，17,886-895)
Comprehensive reviews of neurocognitive outcomes following mild, uncomplicated traumatic brain injury (TBI) in children have shown minimal effects on neurocognition, especially in methodologically rigorous studies. In this study, we report longitudinal (1,6, and 12 months post injury) results in four domains of neurocognitive functioning in a large sample of children with mild TBI (n = 124, ages 8-17 at injury) relative to two demographically matched control groups (other injury: 11 = 94 and non-injury: it = 106). After accounting for age and parental education, significant main effects of group were observed on 7 of the 10 neurocognitive tests. However, these differences were not unique to the TBI sample but were found between both the TBI and other injury groups relative to the non-injured group, suggesting a general injury effect. Effects were primarily within the domains measuring memory, psychomotor processing speed, and language. This is the largest longitudinal study to date of neurocognitive outcomes at discrete time points in pediatric mild TBI. When controlling for pre-injury factors, there is no evidence of long-term neurocognitive impairment in this group relative to another injury control group. The importance of longitudinal analyses and use of appropriate control groups are discussed in the context of evaluating the effects of mild TBI on cognition. (ENS, 2011, 17, 886-895)