Microglia and macrophages in the neuro-glia-vascular unit: From identity to functions
Microglia and macrophages in the neuro-glia-vascular unit: From identity to functions
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DOI：
10.1016/j.nbd.2023.106066
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Yanqin Gao
中科院分区：
文献类型：
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作者：
Shuning Chen;Jiaying Li;Shan Meng;Tingyu He;Ziyu Shi;Chenran Wang;Yana Wang;Hui Cao;Yichen Huang;Yue Zhang;Ye Gong;Yanqin Gao
Although both are myeloid cells located surrounding cerebral vasculature, vessel-associated microglia (VAM) and perivascular macrophages (PVMs) can be distinguished by their distinct morphologies, signatures and microscopic location. As key component of neuro-glia-vascular unit (NGVU), they play prominent roles in neurovasculature development and pathological process of various central nervous system (CNS) diseases, including phagocytosis, angiogenesis, vessel damage/protection and blood flow regulation, therefore serving as potential targets for therapeutics of a broad array of CNS diseases. Herein, we will provide a comprehensive overview of heterogeneity of VAM/PVMs, highlight limitations of current understanding in this field, and discuss possible directions of future investigations.
