The impact of Ets-1 oncoprotein and human endoglin (CD105) on the recurrence of non-melanoma skin cancers
The impact of Ets-1 oncoprotein and human endoglin (CD105) on the recurrence of non-melanoma skin cancers
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DOI：
10.1111/ijd.12891
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发表时间：
2015-09-01
影响因子：
3.6
通讯作者：
Papadopoulos, Othon
中科院分区：
文献类型：
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作者：
Chrisostomidis, Chrisostomos;Konofaos, Petros;Papadopoulos, Othon
背景本研究的目的是探讨CD 105和Ets-1的表达是否是预测非黑色素瘤皮肤癌（NMSC）侵袭性生物学行为的指标，并评估局部复发的指标。手术标本的诊断确认和Ets-1和CD 105的免疫组化表达由两个dermatopathologist.ResultsThe最常见的肿瘤类型是基底细胞癌（n=76），其次是鳞状细胞癌（SCC）（n=65）。最常见的解剖部位是头颈部（n=115）。后续是什么？在所有审查的案件中为2年。肿瘤局部复发与年龄（P=0.03）、Ets-1表达（P？0.0001）和CD 105表达（P？0.0001).结论Ets-1和CD 105均为预测NMSC局部复发的指标。然而，这种说法是谨慎的，需要更多的研究，更大的人群，以检查这两个标志物和局部复发之间的相关性。更好地了解原发性NMSC局部复发的发病机制可能会导致潜在的治疗干预。
BackgroundThe aim of this study was to investigate if the expression of CD105 and Ets-1 was predictive of aggressive biologic behavior of non-melanoma skin cancers (NMSC) and to evaluate indicators of local recurrence.Patients and methodsA total of 144 patients with NMSC were included in the current study. Surgical specimens were independently examined for diagnosis confirmation and immunohistochemical expression of Ets-1 and CD105 by two dermatopathologists.ResultsThe most common tumor type was basal cell carcinoma (n=76), followed by squamous cell carcinomas (SCC) (n=65). The most common anatomic location was the head and neck area (n=115). The follow-up was ?2years in all examined cases. A statistically significant correlation was found between tumor local recurrence and age (P=0.03), Ets-1 expression (P?0.0001) and CD105 expression (P?0.0001).ConclusionsOur data confirm that both Ets-1 and CD105 show promise as prognostic markers for local recurrence of NMSC. However, this statement is made with caution, and additional studies, with larger populations, are necessary to examine the correlation between these two markers and local recurrence. A better understanding of the pathogenesis of local recurrence in primary NMSC may result in potential therapeutic interventions.